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Double Blind Randomized Study Into the Efficacy of Codeine Phosphate Analgesia After Cleft Palate Repair in Infants

2014-08-27 03:42:07 | BioPortfolio

Summary

This study examines the analgesic efficacy of codeine phosphate. It is compared to placebo in infants receiving morphine after surgery. Codeine may be effective enough to make morphine unnecessary.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind

Conditions

Cleft Palate Repair

Intervention

Codeine Phosphate Analgesia

Location

Great Ormond Street Hospital, Anaesthetics
London
United Kingdom
WC1N 1EH

Status

Completed

Source

Institute of Child Health

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:42:07-0400

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Medical and Biotech [MESH] Definitions

Surgery performed to repair or correct the skeletal anomalies of the jaw and its associated dental and facial structures (e.g. CLEFT PALATE).

An autosomal recessive disorder characterized by brachygnathia and cleft palate, often associated with glossoptosis, backward and upward displacement of the larynx, and angulation of the manubrium sterni. Cleft palate makes sucking and swallowing difficult, permitting easy access of fluids into the larynx. It may appear in several syndromes or as an isolated hypoplasia. (Dorland, 27th ed)

Congenital fissure of the soft and/or hard palate, due to faulty fusion.

Surgical procedure to add bone to the ALVEOLAR RIDGE in children born with a CLEFT LIP and a CLEFT PALATE.

Failure of the SOFT PALATE to reach the posterior pharyngeal wall to close the opening between the oral and nasal cavities. Incomplete velopharyngeal closure is primarily related to surgeries (ADENOIDECTOMY; CLEFT PALATE) or an incompetent PALATOPHARYNGEAL SPHINCTER. It is characterized by hypernasal speech.

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