Advertisement

Topics

Transcranial Magnetic Stimulation and Anti-Epileptic Effect: Optimization and Evaluation With Electrophysiology.

2014-08-27 03:42:15 | BioPortfolio

Summary

Epileptic disease is characterised by enhanced brain excitability. Low frequency repetitive transcranial magnetic stimulation (rTMS) can be an effective treatment for refractory frontal epilepsy. Thought, physiological mechanisms of its effectivity are still unknown. It is yet possible to evaluate cortical excitability and inhibition with TMS-coupled electromyography before and after rTMS sessions ; this could provide clues for basic mechanisms of rTMS effects on the epileptic brain. We assume that rTMS decrease brain excitability by improving brain inhibition. Such an information could help for treating patients with both pharmacological and non-pharmacological methods.

Study Design

Allocation: Randomized, Control: Uncontrolled, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Refractory Frontal Lobe Epilepsy

Intervention

cortical magnetic stimulation provided by an eight-shaped coïl placed upon the skull.

Location

Département de Neurologie - Hôpital Civil
Strasbourg
France
67091

Status

Recruiting

Source

University Hospital, Strasbourg, France

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:42:15-0400

Clinical Trials [2211 Associated Clinical Trials listed on BioPortfolio]

Cortical Plasticity Assessment in Athletes With Multiple Concussions

The purpose of this research is to determine whether athletes with concussion have changes in cortical excitability. Single and paired transcranial magnetic stimulation (TMS) can be used ...

The Effects of Repetitive Transcranial Magnetic Stimulation in Healthy Human Subjects

It has been suggested that the therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) are mediated through changes in cortical inhibition (CI). However, in healthy subj...

An Exploration of the Neuroplasticity of Endogenous Analgesia in Health and Chronic Pain

Transcranial magnetic stimulation (TMS) is a neurophysiological tool for studying cortical functions, and in addition, has an analgesic therapeutic effect whose underlying mechanism is unk...

Safety and Effectiveness of Repetitive Transcranial Magnetic Stimulation in the Treatment of Tinnitus

Tinnitus, i.e., the perception of sounds or noise in the absence of auditory stimuli, is a frequent and often severely disabling symptom of different disorders of the auditory system. Ther...

Acoustic Stimulation Paired With Body and Cortical Stimulation for Modulating Tinnitus

The purpose of the study is to investigate different stimulation parameters for a new noninvasive approach for modulating the brain that could potentially be beneficial for decreasing tinn...

PubMed Articles [11711 Associated PubMed Articles listed on BioPortfolio]

Myths and Methodologies: How loud is the story told by the transcranial magnetic stimulation-evoked silent period?

What is the topic of this review? The origin, interpretation and methodological constraints of the silent period induced by transcranial magnetic stimulation are reviewed. What advances does it highli...

Assessing Recurrent Interactions in Cortical Networks: Modeling EEG Response to Transcranial Magnetic Stimulation.

The basic mechanisms underlying the electroencephalograpy (EEG) response to transcranial magnetic stimulation (TMS) of the human cortex are not well understood.

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex.

Transcranial magnetic stimulation (TMS) is a non-invasive method that produces neural excitation in the cortex by means of brief, time-varying magnetic field pulses. The initiation of cortical activat...

Changes in motor cortical excitability in schizophrenia following transcranial direct current stimulation.

Schizophrenia is a disorder associated with cortical inhibition deficits. Transcranial direct current stimulation (tDCS) induces changes in cortical excitability in healthy subjects and individuals wi...

Noninvasive brain stimulation combined with other therapies improves gait speed after stroke: a systematic review and meta-analysis.

Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are noninvasive brain stimulation (NIBS) techniques able to modulate cortical excitability.

Medical and Biotech [MESH] Definitions

Measurable changes in activities in the CEREBRAL CORTEX upon a stimulation. A change in cortical excitability as measured by various techniques (e.g., TRANSCRANIAL MAGNETIC STIMULATION) is associated with brain disorders.

The electrical response evoked in a muscle or motor nerve by electrical or magnetic stimulation. Common methods of stimulation are by transcranial electrical and TRANSCRANIAL MAGNETIC STIMULATION. It is often used for monitoring during neurosurgery.

The decrease in neuronal activity (related to a decrease in metabolic demand) extending from the site of cortical stimulation. It is believed to be responsible for the decrease in cerebral blood flow that accompanies the aura of MIGRAINE WITH AURA. (Campbell's Psychiatric Dictionary, 8th ed.)

Cortical malformations secondary to abnormal cortical maturation after CELL MIGRATION in NEUROGENESIS. This group includes injury to the cortex during later stages of cortical development such as POLYMICROGYRIA and focal cortical dysplasias.

Cortical vigilance or readiness of tone, presumed to be in response to sensory stimulation via the reticular activating system.

More From BioPortfolio on "Transcranial Magnetic Stimulation and Anti-Epileptic Effect: Optimization and Evaluation With Electrophysiology."

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Alzheimer's Disease
Of all the types of Dementia, Alzheimer's disease is the most common, affecting around 465,000 people in the UK. Neurons in the brain die, becuase  'plaques' and 'tangles' (mis-folded proteins) form in the brain. People with Al...

Epilepsy
Epilepsy is defined as a disorder of brain function characterized by recurrent seizures that have a sudden onset.  (Oxford Medical Dictionary).  A seizure is caused by a sudden burst of excess electrical activity in the brain, causing a tempora...


Searches Linking to this Trial