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During laparoscopy, administration of cold and dry carbon dioxide (CO2) leads to hypothermia. Different types of gas conditioning have been studied in order to prevent this specific hypothermia. Intra-abdominal administration of local anesthetics has also been studied in order to prevent post-operative pain. In both cases, some results have been described.
The investigators propose to evaluate in a prospective, randomized, double blind trial, the impact of 4 different types of conditioning of insufflated gas during laparoscopy for womb surgery on hypothermia prevention and post-operative pain. These 4 types of gas conditioning are:
- CO2 wet and warm with nebulized ropivacaïne
- CO2 wet and warm without nebulized ropivacaïne
- CO2 dry and cold with nebulized ropivacaïne
- CO2 dry and cold without nebulized ropivacaïne
The investigators use a new device (Aeroneb® Pro [Aerogen® Company]) which can wet (by nebulization) the insufflated gas and therefore permits intraperitoneal medicament administration (local anesthetics).
Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
ropivacaïne 0.75% (Naropeine), womb operation by laparoscopy, Aeroneb® Pro (Aerogen® Company)
University Hospital, Strasbourg, France
Published on BioPortfolio: 2014-07-24T14:23:59-0400
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