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VEGF Trap in Treating Patients With Metastatic Breast Cancer

2014-08-27 03:42:49 | BioPortfolio

Summary

RATIONALE: VEGF Trap may stop the growth of tumor cells by blocking blood flow to the tumor.

PURPOSE: This phase II trial is studying how well VEGF Trap works in treating patients with metastatic breast cancer.

Description

OBJECTIVES:

Primary

- Assess the antitumor activity of VEGF Trap, in terms of tumor response rate, in patients with metastatic breast cancer who have received ≤ 2 prior chemotherapy regimens for metastatic disease, including a taxane and/or anthracycline.

- Assess the 6-month progression-free survival rate in patients treated with VEGF Trap.

Secondary

- Describe the adverse event profile (grade using the NCI CTCAE version 3.0) of VEGF Trap in these patients.

- Describe the progression-free survival times in patients treated with VEGF Trap.

- Describe the overall survival of patients treated with VEGF Trap.

- Describe the duration of response in patients treated with VEGF Trap.

OUTLINE: This is a multicenter study.

Patients receive VEGF Trap IV over 1 hour on day 1. Courses repeat every 14 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed every 3-6 months for up to 5 years.

PROJECTED ACCRUAL: A total of 45 patients will be accrued for this study.

Study Design

Masking: Open Label, Primary Purpose: Treatment

Conditions

Breast Cancer

Intervention

aflibercept

Location

Mayo Clinic Scottsdale
Scottsdale
Arizona
United States
85259-5499

Status

Active, not recruiting

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:42:49-0400

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