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RATIONALE: VEGF Trap may stop the growth of tumor cells by blocking blood flow to the tumor.
- Assess the antitumor activity of VEGF Trap, in terms of tumor response rate, in patients with metastatic breast cancer who have received ≤ 2 prior chemotherapy regimens for metastatic disease, including a taxane and/or anthracycline.
- Assess the 6-month progression-free survival rate in patients treated with VEGF Trap.
- Describe the adverse event profile (grade using the NCI CTCAE version 3.0) of VEGF Trap in these patients.
- Describe the progression-free survival times in patients treated with VEGF Trap.
- Describe the overall survival of patients treated with VEGF Trap.
- Describe the duration of response in patients treated with VEGF Trap.
OUTLINE: This is a multicenter study.
Patients receive VEGF Trap IV over 1 hour on day 1. Courses repeat every 14 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed every 3-6 months for up to 5 years.
PROJECTED ACCRUAL: A total of 45 patients will be accrued for this study.
Masking: Open Label, Primary Purpose: Treatment
Mayo Clinic Scottsdale
Active, not recruiting
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:42:49-0400
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