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Study of Nitazoxanide in the Treatment of Amebiasis in Adults and Adolescents

2010-07-15 17:00:00 | BioPortfolio

Summary

The purpose of this study is to determine the effect of nitazoxanide tablets in treating diarrhea caused by Entamoeba histolytica in adults and adolescents.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Conditions

Amebiasis

Intervention

Nitazoxanide

Location

University Hospital
Alexandria
Egypt

Status

Completed

Source

Romark Laboratories L.C.

Results (where available)

View Results

Links

Published on BioPortfolio: 2010-07-15T17:00:00-0400

Clinical Trials [23 Associated Clinical Trials listed on BioPortfolio]

Study of Nitazoxanide in the Treatment of Amebiasis in Children

The purpose of this study is to determine the effect of nitazoxanide suspension in treating diarrhea caused by Entamoeba histolytica in children.

4-Week Lead-In With Nitazoxanide Followed by 36 Weeks Nitazoxanide and Peginterferon Alfa-2a in Chronic Hepatitis C

The purpose of this study is to determine if taking nitazoxanide alone for 4 weeks followed by 36 weeks of nitazoxanide plus peginterferon is superior to peginterferon plus ribavirin (stan...

A 14 Day Early Bactericidal Activity Study of Nitazoxanide for the Treatment of Tuberculosis

This research is being done to determine if Nitazoxanide (NTZ) will cause a significant decrease in the number of M. tuberculosis bacteria in sputum after 14 days of treatment. The study i...

A Study to Evaluate the Use of Nitazoxanide to Treat Cryptosporidiosis

The purpose of this study is to see if nitazoxanide (NTZ) can be used to treat AIDS patients suffering from cryptosporidiosis (diarrhea caused by the parasite Cryptosporidium).

Compassionate Use of Nitazoxanide for the Treatment of Clostridium Difficile Infection

The purpose of this study is for compassionate use of nitazoxanide in the treatment of diarrheal disease due to Clostridium difficile infection when the patient has failed previous treatme...

PubMed Articles [19 Associated PubMed Articles listed on BioPortfolio]

Case Report: Endemic Amebiasis in Australia: Implications for Residents, Travelers, and Clinicians.

Entamoeba histolytica is considered endemic in Australia; however, cases are rare, occurring almost exclusively in high-risk individuals. We describe a series of locally acquired, complicated cases in...

Nitazoxanide is active against Mycobacterium leprae.

Nitazoxanide (NTZ) is an anti-parasitic drug that also has activity against bacteria, including Mycobacterium tuberculosis. Our data using both radiorespirometry and live-dead staining in vitro demons...

Rotavirus Infection in Pediatric Allogeneic Hematopoietic Cell Transplant Recipients: Clinical Course and Experience Using Nitazoxanide and Enterally Administered Immunoglobulins.

Rotaviruses may produce prolonged and severe disease in allogeneic hematopoietic stem cell transplant (HCT) recipients. Nitazoxanide and enterally administered human immunoglobulins are potential ther...

A case of amebiasis with negative serologic markers that caused intra-abdominal abscess.

A 23-year-old Japanese woman presented with abdominal distention following fever, diarrhea, and abdominal pain during a stay in Taiwan. Serology for the detection of amebic-antibodies and stool micros...

The susceptibility of circulating human influenza viruses to tizoxanide, the active metabolite of nitazoxanide.

Nitazoxanide is a thiazolide compound that was originally developed as an anti-parasitic agent, but has recently been repurposed for the treatment of influenza virus infections. Thought to exert its a...

Medical and Biotech [MESH] Definitions

Agents which are destructive to amebae, especially the parasitic species causing AMEBIASIS in man and animal.

Infection with any of various amebae. It is an asymptomatic carrier state in most individuals, but diseases ranging from chronic, mild diarrhea to fulminant dysentery may occur.

Single or multiple areas of PUS due to infection by any ameboid protozoa (AMEBIASIS). A common form is caused by the ingestion of ENTAMOEBA HISTOLYTICA.

A species of free-living soil amoeba in the family Balamuthiidae, causing AMEBIASIS and a deadly form of ENCEPHALITIS in humans.

8-Hydroxyquinolinols chlorinated on the number 5 and/or 7 carbon atom(s). They are antibacterial, antiprotozoal, and antidiarrheal, especially in amebiasis, and have also been used as antiseborrheics. The compounds are mostly used topically, but have been used also as animal feed additives. They may cause optic and other neuropathies and are most frequently administered in combination with other agents.

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