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Moderate alcohol consumption is associated with a decreased risk of diabetes type 2. This association could be mediated by an improvement of insulin sensitivity with moderate alcohol consumption. Patients with diabetes type 2 or impaired glucose tolerance often may have decreased fat oxidative capacity or oxidative phosphorylation in tissue such as muscle. This could lead to accumulation triglyceride storage in muscle, which could interfere with insulin signaling. Whether such mechanism can also play a role with moderate alcohol consumption is unknown and will be investigated in this study.
In addition, moderate alcohol consumption with a meal can lead to delayed hypoglycemia in type 1 diabetes patients. How moderate alcohol consumption affects postprandial glycemic response in healthy subjects is unknown. This is a secondary objective of this trial.
To investigate the effect of moderate alcohol consumption on
- enzymes involved in fatty acid oxidation, oxidative phosphorylation and glycolysis in skeletal muscle
- transporters of fatty acids and glucose in fat tissue
- post-prandial glycemic response in healthy, lean or overweight, young men
Design : Open, randomized, partially diet-controlled, placebo controlled cross-over design
- Description : Healthy, lean and overweight young (18-40 years) men
- Number : 20
- Test substance : 100 ml whiskey (Famous Grouse, 40% v/v alcohol: ≈ 32 g alcohol)
- Reference substance : 100 ml mineral water (Spa blauw)
Duration: 2 treatment periods of 4 weeks (28 days)
- Muscle biopsy for activity of 3-hydroxy fatty-acyl CoA dehydrogenase, citrate synthase, cytochrome c oxidase
- Postprandial glycemic response (glucose, insulin, GLP-1, GLP-2, GIP, glucagon, FFA etc.)
- Insulin sensitivity and related factors (oral glucose tolerance test, adiponectin, HbA1c)
- Liver enzymes (safety)
- Body weight
- Urinary ethyl glucuronide (compliance)
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Prevention
Diabetes Mellitus, Type 2
TNO Quality of Life
Published on BioPortfolio: 2014-08-27T03:43:01-0400
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A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
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