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Drug Interaction Study With Proton Pump Inhibitor

2014-08-27 03:43:17 | BioPortfolio

Summary

The purpose of this clinical research study is to assess the effect of omeprazole at 20 mg on the pharmacokinetics of atazanavir administered as atazanavir with ritonavir relative to atazanavir or atazanavir/ritonavir in the absence of omeprazole in healthy subjects.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Parallel Assignment, Masking: Open Label

Conditions

HIV Infections

Intervention

Atazanavir, Atazanavir/Ritonavir, Atazanavir/Ritonavir+Omeprazole, Atazanavir/Ritonavir+Omeprazole, Atazanavir, Atazanavir/Ritonavir, Atazanavir/Ritonavir+Omeprazole, Atazanavir/Ritonavir+Omeprazole

Location

Local Institution
Hamilton
New Jersey
United States

Status

Completed

Source

Bristol-Myers Squibb

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:43:17-0400

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Medical and Biotech [MESH] Definitions

An azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS.

An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV.

An HIV protease inhibitor used in a fixed-dose combination with RITONAVIR. It is also an inhibitor of CYTOCHROME P-450 CYP3A.

The S-isomer of omeprazole.

A highly effective inhibitor of gastric acid secretion used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-EXCHANGING ATPASE) in the proton pump of GASTRIC PARIETAL CELLS.

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