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Effect of Rosuvastatin in Abdominal Sepsis

2014-08-27 03:43:17 | BioPortfolio

Summary

The purpose of this study is to determine whether rosuvastatin is effective such a coadjuvant drug in the integral management of abdominal sepsis acknowledged by surgery.

Description

The sepsis is often lethal, the mortality's ranks are identified among 25 to 70%, this depends on definition, severity and co-morbidities. The number of deaths by sepsis could be similar to myocardial infarct. Patients who get shock have 26-fold risk of death.

In preliminary studies have been observed, that patients with treatment with statin have minor incidence of severe sepsis. A retrospective study suggest the association between using statins and reduction of bacteriemia by Gram negatives and S. aureus.

There are many experimental studies which demonstrate the possible profit in sepsis. However there are no clinical prospective studies for determinate if statins are effective in management of sepsis. We design this study for demonstrate the utility if rosuvastatin in one kind of sepsis, abdominal sepsis.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Sepsis

Intervention

Rosuvastatin

Location

Hospital Central "Dr. Ignacio Morones Prieto
San Luis Potosi
Mexico
78240

Status

Completed

Source

Universidad Autonoma de San Luis Potosí

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:43:17-0400

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A HYDROXYMETHYLGLUTARYL-COA-REDUCTASE INHIBITOR, or statin, that reduces the plasma concentrations of LDL-CHOLESTEROL; APOLIPOPROTEIN B, and TRIGLYCERIDES while increasing HDL-CHOLESTEROL levels in patients with HYPERCHOLESTEROLEMIA and those at risk for CARDIOVASCULAR DISEASES.

Test to determine the presence of blood infection (e.g. SEPSIS; BACTEREMIA).

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