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RATIONALE: Exposure to trichloroethylene in the workplace may increase the risk of damaging white blood cells. Learning about the long-term effects of trichloroethylene exposure in factory workers in Guangdong Province, China, may help doctors learn more about the risks of this substance.
PURPOSE: This clinical trial is studying exposure to trichloroethylene in factory workers in Guangdong Province, China.
- To determine if trichloroethylene (TCE) exposure increases chromosomal aberrations in peripheral blood lymphocytes in blood samples from factory workers in Guangdong Province, China.
- To determine if TCE exposure alters levels of key cytokines in plasma and changes lymphocyte subset ratios in the blood samples of these participants.
- To determine intermediate and early biologic effect biomarkers of genotoxicity and immunotoxicity as well as biomarkers of susceptibility in the blood and urine samples of these participants.
OUTLINE: Participants wear small instruments at work that measure chemicals in the air for 1 or 2 days during the 2-week study period to assess the trichloroethylene exposure levels quantitatively. Participants who have been exposed to trichloroethylene also wear several small skin patches on 1 of the 2 days. Participants also complete a questionnaire related to other exposure information (e.g., work information, smoking and drinking habits, use of medicines, medical history, general health, hobbies, and exposure to radiation and other substances at home). Blood and urine samples are collected to assay a series of biomarkers of susceptibility and to determine intermediate and early biologic effects.
Health Status Unknown
cytogenetic analysis, molecular diagnostic method, laboratory biomarker analysis, questionnaire administration, study of high risk factors
Guangdong National Poison Control Center (NPCC)
Active, not recruiting
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:43:29-0400
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