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A Study of the Effect of Time on Topical Anesthetic Efficacy.

2014-08-27 03:43:29 | BioPortfolio

Summary

This is a study of the effect of time on the effectiveness of topical anesthetics in the mouth. The Null Hypothesis is: Regardless of the time of application over a 10-minute period, there is no difference in the clinical effectiveness of the topical anesthetic 5% lidocaine on (a) the pain of needle stick insertion and (b) the pain of local anaesthetic administration.

Description

The study design will be a double blind randomized controlled split-mouth clinical trial. It is proposed to compare the effectiveness of the standard topical anesthetic 5% lidocaine with a placebo over the time period of 2, 5 and 10 minutes after application. The topical will be placed on the palatal soft tissue where the perception of pain is the highest in the oral cavity. Both the pain of needle insertion and the pain of local anesthetic injection will be compared.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Educational/Counseling/Training

Conditions

Pain

Intervention

lidocaine topical

Location

Faculty of Dentistry
Toronto
Ontario
Canada
M5G 1G6

Status

Recruiting

Source

University of Toronto

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:43:29-0400

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Medical and Biotech [MESH] Definitions

A colorless liquid with a sharp burning taste and slight odor. It is used as a local anesthetic and to reduce pain associated with LIDOCAINE injection. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.

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Fluorides, usually in pastes or gels, used for topical application to reduce the incidence of DENTAL CARIES.

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Dull or sharp aching pain caused by stimulated NOCICEPTORS due to tissue injury, inflammation or diseases. It can be divided into somatic or tissue pain and VISCERAL PAIN.

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