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Pharmacokinetics of Apricitabine and Tipranavir When Dosed Alone or Together

2014-08-27 03:43:30 | BioPortfolio

Summary

The aim of the study is to see if apricitabine or tipranavir affect the levels of each other in the blood (pharmacokinetic interaction) when they are dosed together.

Description

Apricitabine is a new NRTI in development for treatment of drug resistant HIV. Tipranavir is a recently licensed protease inhibitor for treatment of drug resistant HIV. Tipranavir affects the plasma concentration of some other drugs when they are used together with tipranavir. This study will examine whether the pharmacokinetics of apricitabine are changed when it is dosed together with tipranavir compared to apricitabine alone. Also, the pharmacokinetics of tipranavir will be examined at steady state when it is dosed alone and when it is dosed together with apricitabine. Information on the safety and tolerability of the two drugs when dosed together will also be obtained.

Study Design

Allocation: Non-Randomized, Control: Dose Comparison, Endpoint Classification: Bio-equivalence Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

HIV Infection

Intervention

apricitabine

Location

Jasper Clinic Inc
Kalamazoo
Michigan
United States

Status

Completed

Source

Avexa

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:43:30-0400

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