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Effects of Inhibition of NO-Synthesis on Renal Hemodynamics and Sodium Excretion in Patients With Essential Hypertension and Healthy Controls

2014-08-27 03:43:48 | BioPortfolio

Summary

The study tests the hypothesis that systemic and renal nitric oxide synthesis is changed in essential hypertension by investigating the effects of a non selective nitric oxide inhibitor on renal hemodynamics and sodium excretion in patients with essential hypertension. The results are compared with a group of healthy subjects.

Description

The study investigates the effects of Ng-monomethyl-L-arginine (L-NMMA) on:

1. renal hemodynamics (renal plasma flow and glomerular filtration rate)

2. renal sodium excretion

3. lithium clearance and fractional lithium excretion

4. plasma levels of vasoactive hormones

5. blood pressure and heart rate

Study Design

Allocation: Randomized, Control: Placebo Control, Intervention Model: Crossover Assignment, Masking: Single Blind

Conditions

Hypertension

Intervention

Ng-monomethyl-L-arginine (drug)

Status

Completed

Source

Holstebro Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:43:48-0400

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Medical and Biotech [MESH] Definitions

A cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.

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