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Desmopressin in Cardiac Surgery

2014-08-27 03:44:08 | BioPortfolio

Summary

Patients undergoing cardiac surgery could develop excessive perioperative bleeding requiring transfusions of blood products.

Desmopressin (DDAVP), already used for patients with von Willebrand syndrome, could reduce bleeding and transfusion requirements in these patients when administered ev (0.3 mg/kg) in 20-30 minutes postoperatively.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Conditions

Hemorrhage

Intervention

Desmopressin (DDAVP), Placebo Comparator

Location

Istituto Ospedaliero Fondazione Poliambulanza
Brescia
Italy
20132

Status

Recruiting

Source

Università Vita-Salute San Raffaele

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:44:08-0400

Clinical Trials [770 Associated Clinical Trials listed on BioPortfolio]

Improving Platelet Activity for Cerebral Hemorrhage Treatment - DDAVP Proof of Concept

The investigators intend to show that DDAVP improves platelet activity from baseline to 30-60 minutes after treatment.

Characterization of Laboratory Response to DDAVP in Adult Hemophilia A Carriers

The purpose of this study is to determine how female hemophilia A carriers respond to a medication called DDAVP (Desmopressin).

Desmopressin Acetate 0.2 mg Tablets, Fasting

The objective of this study was to compare the single-dose relative bioavailability of TEVA and Aventis Pharmaceuticals (DDAVP®) 0.2 mg desmopressin acetate tablets following a 0.8 mg dos...

Exercise Versus DDAVP in Patients With Mild Hemophilia A

Individuals with mild hemophilia A (MHA) bleed infrequently but can in the setting of trauma which often is when participating in sports/exercise. Although both exercise and DDAVP (desmopr...

Desmopressin as Treatment for Postoperative Bleeding After Cardiac Surgery

Some patients undergoing cardiac surgery develop excessive postoperative bleeding. Cardiopulmonary bypass causes platelet dysfunction. Several studies have documented the ability of desmop...

PubMed Articles [1622 Associated PubMed Articles listed on BioPortfolio]

Desmopressin, alarm, desmopressin plus alarm, and desmopressin plus anticholinergic agent in the management of pediatrics monosymptomatic nocturnal enuresis: a network meta-analysis.

To assess the efficacy of desmopressin (D), alarm (A), desmopressin plus alarm (DA), and desmopressin plus anticholinergic agent (DAA) in the management of pediatrics monosymptomatic nocturnal enuresi...

A Comparator-Hypothesis Account of Biased Contingency Detection.

Our ability to detect statistical dependencies between different events in the environment is strongly biased by the number of coincidences between them. Even when there is no true covariation between...

Preclinical Efficacy of V4Q5dDAVP, a Second Generation Vasopressin Analog, on Metastatic Spread and Tumor-Associated Angiogenesis in Colorectal Cancer.

Control of metastatic spread of colorectal cancer (CRC) remains as a major therapeutic challenge. [V4Q5]dDAVP is a vasopressin peptide analog with previously reported anticancer activity against carci...

Systematic Evaluation of Desmopressin Applied to the Patients with Aneurysmal Subarachnoid Haemorrhage in the light of the Literature.

This study discusses the management of patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH), developed after subarachnoid hemorrhage, in a comparative manner in light of ...

Pharmacokinetic Modelling to Predict FVIII:C Response to Desmopressin and Its Reproducibility in Nonsevere Haemophilia A Patients.

 Nonsevere haemophilia A (HA) patients can be treated with desmopressin. Response of factor VIII activity (FVIII:C) differs between patients and is difficult to predict.

Medical and Biotech [MESH] Definitions

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

Hemorrhage within the orbital cavity, posterior to the eyeball.

Intraocular hemorrhage from the vessels of various tissues of the eye.

Hemorrhage following any surgical procedure. It may be immediate or delayed and is not restricted to the surgical wound.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

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