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Secondary Prevention of Venous Thrombo Embolism.

2014-08-27 03:44:28 | BioPortfolio

Summary

The general aim of this study is to determine the comparative safety and efficacy of dabigatran etex ilate administered orally and warfarin (INR of 2.0-3.0) for the long-term treatment and secondary pr evention of symptomatic venous thromboembolism in patients who have been successfully treated with s tandard doses of an approved anticoagulant for three to six months for confirmed acute symptomatic V enous Thrombo-embolism.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Conditions

Thromboembolism

Intervention

Dabigatran, Warfarin

Location

1160.47.01035 Boehringer Ingelheim Investigational Site
Mobile
Alabama
United States

Status

Active, not recruiting

Source

Boehringer Ingelheim Pharmaceuticals

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:44:28-0400

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Efficacy and Safety of Dabigatran Compared to Warfarin for 6 Month Treatment of Acute Symptomatic Venous Thromboembolism

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Comparative Effectiveness and Safety Between Warfarin and Dabigatran

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Dabigatran Versus Warfarin With NVAF Who Undergo PCI

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PubMed Articles [440 Associated PubMed Articles listed on BioPortfolio]

Dabigatran, Rivaroxaban, and Warfarin in the Oldest Adults with Atrial Fibrillation in Taiwan.

To compare the effectiveness and safety of reduced-dose dabigatran, reduced-dose rivaroxaban, and warfarin in individuals aged 85 and older with atrial fibrillation (AF).

Evaluation of the Bleeding Intensity of Patients Anticoagulated with Warfarin or Dabigatran Undergoing Dental Procedures.

Thrombotic disorders remain one of the leading causes of death in the Western world. Dabigatran appeared as an alternative to warfarin for anticoagulation in the treatment of atrial fibrillation (AF)....

Management of dabigatran after overdosage: two case reports and suggestions for monitoring.

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Effectiveness and safety of rivaroxaban versus warfarin in patients with unprovoked venous thromboembolism: A propensity-score weighted administrative claims cohort study.

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Medical and Biotech [MESH] Definitions

An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.

A THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.

A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233)

A coumarin that is used as an anticoagulant. It has actions similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226)

Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.

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