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RATIONALE: Drugs used in chemotherapy, such as topotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving topotecan directly into the tumor and surrounding tissue may kill more tumor cells.
PURPOSE: This phase I trial is studying the side effects of topotecan infused directly into the tumor and surrounding tissue in treating patients with refractory or progressive primary malignant brain tumors.
- Evaluate the safety and effectiveness of convection enhanced delivery (intracerebral clysis [ICC]) therapy comprising topotecan hydrochloride in patients with refractory or progressive primary malignant brain tumors.
- Apply advanced MRI as a noninvasive means of optimizing treatment parameters and determining volume of drug distribution with convection enhanced delivery.
- Determine whether the expression of the topoisomerase target in the tumor influences response to topotecan hydrochloride.
OUTLINE: This is an open-label study.
Patients undergo placement of two catheters inserted directly into the tumor and surrounding tissue. Patients receive topotecan hydrochloride via convection enhanced delivery continuously for up to 5 days. Patients are monitored daily for response and drug distribution by MRI.
PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.
Masking: Open Label, Primary Purpose: Treatment
Brain and Central Nervous System Tumors
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:44:47-0400
RATIONALE: Drugs used in chemotherapy, such as carboplatin and topotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from div...
RATIONALE: Drugs used in chemotherapy, such as topotecan, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. PURPOSE...
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of intrathecal o...
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: This phase II trial is studying how well topotecan works i...
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