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Buprenorphine in the Treatment of Osteoarthritis (OA) in the Elderly

2014-08-27 03:44:48 | BioPortfolio

Summary

The primary objective is to compare buprenorphine transdermal delivery system (BTDS) with standard- treatment in subjects with osteoarthritis (OA).

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Osteoarthritis

Intervention

Buprenorphine, Codeine paracetamol

Location

Napp Pharmaceuticals Ltd
Cambridge
United Kingdom
CB4 0GW

Status

Completed

Source

Napp Pharmaceuticals Limited

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:44:48-0400

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Medical and Biotech [MESH] Definitions

Semisynthetic derivative of CODEINE that acts as a narcotic analgesic more potent and addicting than codeine.

A pharmaceutical preparation that combines buprenorphine, an OPIOID ANALGESIC with naloxone, a NARCOTIC ANTAGONIST to reduce the potential for NARCOTIC DEPENDENCE in the treatment of pain. It may also be used for OPIATE SUBSTITUTION THERAPY.

A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.

Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.

An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.

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