Prophylactic Effect of Memantine in Chronic Tension-Type Headache

2014-08-27 03:45:09 | BioPortfolio


The purpose of this study is to test whether memantine has a prophylactic effect on chronic tension-type headaches.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment


Tension-Type Headache




Danish Headaches Center




Danish Headache Center

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:45:09-0400

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Correction: Anxiety and the severity of Tension-Type Headache mediate the relation between headache presenteeism and workers' productivity.

[This corrects the article DOI: 10.1371/journal.pone.0201189.].

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Medical and Biotech [MESH] Definitions

A common primary headache disorder, characterized by a dull, non-pulsatile, diffuse, band-like (or vice-like) PAIN of mild to moderate intensity in the HEAD; SCALP; or NECK. The subtypes are classified by frequency and severity of symptoms. There is no clear cause even though it has been associated with MUSCLE CONTRACTION and stress. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)

Various conditions with the symptom of HEADACHE. Headache disorders are classified into major groups, such as PRIMARY HEADACHE DISORDERS (based on characteristics of their headache symptoms) and SECONDARY HEADACHE DISORDERS (based on their etiologies). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)

AMANTADINE derivative that has some dopaminergic effects. It has been proposed as an antiparkinson agent.

Conditions in which the primary symptom is HEADACHE and the headache cannot be attributed to any known causes.

Secondary headache attributed to TRAUMA of the HEAD and/or the NECK.

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