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Genomics, Single Nucleotide Polymorphisms (SNPs), and Clinical Neonatology

2014-08-27 03:45:10 | BioPortfolio

Summary

This research seeks to establish a neonatal DNA Tissue Bank to find out if differences in small segments of DNA predispose babies to Chronic Lung Disease (CLD), Periventricular Brain Injury (PVI), Necrotizing Enterocolitis (NEC), or Hypoxic Respiratory Failure (HRF).

Description

This genetic predisposition study does not involve investigational drugs, devices, or treatments. Our broad goal is to identify genomic factors, which contribute to the development or exacerbation of common and critical illnesses that affect preterm and near-term infants. We seek to accomplish this goal in the following ways:

- First: to test candidate gene DNA variations and link already identified single nucleotide polymorphisms (SNPs) producing functional alterations to the risk of clinically important disorders.

- Second: to utilize a whole-genomic approach to identify SNPs not previously linked to the risk of development or progression of neonatal disorders.

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Conditions

Lung Disease

Location

Children's Mercy Hospitals and Clinics
Kansas City
Missouri
United States
64108

Status

Recruiting

Source

Children's Mercy Hospital Kansas City

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:45:10-0400

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