Advertisement

Topics

Patient-Centered Implementation Trial for Single Embryo Transfer

2014-08-27 03:45:10 | BioPortfolio

Summary

Background: The number of multiple pregnancies is considered to be the most important adverse effect of in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI). IVF or ICSI with transferring only one embryo, elective single embryo transfer (eSET), will reduce this incidence remarkably. Unfortunately, former research has documented that cycles with SET maintain lower pregnancy rates compared to double embryo transfer (DET). Implementation of eSET will require a carefully chosen and thoroughly defined implementation strategy focussed on the couple undergoing the subfertility treatment. This trial will investigate the (cost)effectiveness of a combined patient centred implementation strategy.

Objective: The main aim is to compare the effectiveness and costs of implementation of elective single embryo transfer (eSET) in in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI), between usual care and a combined patient-centred strategy.

Study design: A randomised controlled trial

Study population: Couples with a female age less than 40 years ongoing an IVF/ICSI treatment in 2 of the 13 Dutch IVF centres and their 4 satellite/transport centres.

Intervention A combined patient centred implementation strategy for eSET in IVF/ICSI. The strategy consists of counselling through an evidence based decision aid and reimbursement of a 4th cycle if couples have chosen for eSET in the first 2 cycles.

Primary study parameters/outcome of the study: the eSET occurrence rate, pregnancy outcomes and cost-effectiveness of the combined strategy.

Secondary study parameters/outcome of the study:

- patient knowledge

- patient decisional conflict

- patient satisfaction

- IVF/ICSI treatment outcome.

Description

see above

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Conditions

Male Infertility

Intervention

evidence based decision aid, Possible reimbursement 4th IVF/ICSI cycle when necessary

Location

Catharina ziekenhuis Eindhoven
Eindhoven
Netherlands
6500HB

Status

Completed

Source

Radboud University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:45:10-0400

Clinical Trials [1344 Associated Clinical Trials listed on BioPortfolio]

Effects of PGS2.0 in Patients With Unexplained RPL

50%-60% of the known causes of recurrent pregnancy loss(RPL) are associated with embryonic aneuploidy, such that preimplantation genetic screening (PGS) on embryos acquired by assisted rep...

A Comparison of Cost - Effectiveness of Stimulated ICSI and IVM Strategy in PCOS Women

In polycystic ovary syndrome (PCOS) patients, both in vitro maturation (IVM) and intra-cytoplasmic sperm injection (ICSI) are indicated as optional treatments. Although recently ICSI techn...

Evaluating the Impact of Evidence-based Information About PSA Testing on Prostate Cancer Screening Decisions

Patient decision aids are tools that help guide individuals through a healthcare-related decision making process. They help users combine evidence-based information and recommendations by ...

Evaluating the Impact of Evidence-based Information About Mammography on Breast Cancer Screening Decisions

Patient decision aids are tools that help guide individuals through a healthcare-related decision making process. They help users combine evidence-based information and recommendations by ...

ICSI Versus Conventional IVF in Non-male Factor Couples

Conventionally, ICSI was initially developed and has been shown to be an effective treatment for male factor infertility. It is increasingly being used for patients without a male factor d...

PubMed Articles [24023 Associated PubMed Articles listed on BioPortfolio]

Prices For Common Cardiovascular Drugs In The US Are Not Consistently Aligned With Value.

Health care reimbursement agencies in countries other than the US often rely on cost-effectiveness evidence for drug coverage decisions, signaling to drug manufacturers their expectations for value-ba...

Management Practices to Build Evidence-Based Decision-Making Capacity for Chronic Disease Prevention in Georgia: A Case Study.

Research shows that training can improve skills needed for evidence-based decision making, but less is known about instituting organizational supports to build capacity for evidence-based chronic dise...

Key considerations in reimbursement decision-making for multiple sclerosis drugs in Australia.

In Australia, the Pharmaceutical Benefits Advisory Committee (PBAC) advises on the reimbursement of drugs to be subsidised through the Pharmaceutical Benefits Scheme (PBS). This study aims to provide ...

Drug attributes associated with the selection of drugs for reimbursement: A pilot stated preferences experiment with Canadian stakeholders.

Health Technologies Assessment requires that evidence about clinical, economic, social and organizational aspects be considered and weighted in the selection of drugs for reimbursement. We investigate...

Socioeconomic distribution of GP visits following patient choice reform and differences in reimbursement models: Evidence from Sweden.

This study aims to analyse changes in the socioeconomic distribution of GP visits following primary care patient choice reform, and to compare their magnitude and direction in pure capitation, versus ...

Medical and Biotech [MESH] Definitions

The period from onset of one menstrual bleeding (MENSTRUATION) to the next in an ovulating woman or female primate. The menstrual cycle is regulated by endocrine interactions of the HYPOTHALAMUS; the PITUITARY GLAND; the ovaries; and the genital tract. The menstrual cycle is divided by OVULATION into two phases. Based on the endocrine status of the OVARY, there is a FOLLICULAR PHASE and a LUTEAL PHASE. Based on the response in the ENDOMETRIUM, the menstrual cycle is divided into a proliferative and a secretory phase.

Processes or methods of reimbursement for services rendered or equipment.

A graphic device used in decision analysis, series of decision options are represented as branches (hierarchical).

Mathematical or statistical procedures used as aids in making a decision. They are frequently used in medical decision-making.

A system wherein reimbursement rates are set, for a given period of time, prior to the circumstances giving rise to actual reimbursement claims.

More From BioPortfolio on "Patient-Centered Implementation Trial for Single Embryo Transfer"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topic

Women's Health
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...


Searches Linking to this Trial