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Thalamic Deep Brain Stimulation for Tourette Syndrome

2014-08-27 03:45:17 | BioPortfolio

Summary

The purpose of this study is to determine whether deep brain stimulation is effective at reducing tic frequency and severity in adults with Tourette syndrome.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Conditions

Tourette Syndrome

Intervention

Thalamic deep brain stimulation

Location

University Hospitals of Cleveland
Cleveland
Ohio
United States
44106

Status

Completed

Source

University Hospitals of Cleveland

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:45:17-0400

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Medical and Biotech [MESH] Definitions

Therapy for MOVEMENT DISORDERS, especially PARKINSON DISEASE, that applies electricity via stereotactic implantation of ELECTRODES in specific areas of the BRAIN such as the THALAMUS. The electrodes are attached to a neurostimulator placed subcutaneously.

Stimulation of the brain, which is self-administered. The stimulation may result in negative or positive reinforcement.

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.

A technique of brain electric stimulation therapy which uses constant, low current delivered via ELECTRODES placed on various locations on the scalp.

The largest of the medial nuclei of the thalamus. It makes extensive connections with most of the other thalamic nuclei.

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