Low-Dose Radiation Therapy in Treating Patients With Follicular Non-Hodgkin's Lymphoma

2014-08-27 03:45:23 | BioPortfolio


RATIONALE: Radiation therapy uses high-energy x-rays to kill cancer cells. It is not yet known which regimen of low-dose radiation therapy is more effective in treating follicular non-Hodgkin's lymphoma.

PURPOSE: This randomized phase III trial is studying two different regimens of low-dose radiation therapy to compare how well they work in treating patients with follicular non-Hodgkin's lymphoma.




- Compare the local progression-free interval in patients with follicular non-Hodgkin's lymphoma (NHL) treated with 2 different regimens of low-dose radiotherapy.


- Compare acute toxicity at 4 weeks in patients treated with these regimens.

- Compare late toxicity in patients treated with these regimens.

- Compare tumor response at 12 weeks in patients treated with these regimens.

- Compare overall survival in patients treated with these regimens.

- Assess the health economics of these regimens in these patients.

OUTLINE: This is a multicenter, randomized study. Patients are randomized to one of two treatment arms.

- Arm I : Patients undergo low-dose radiotherapy once daily on days 1 and 2.

- Arm II : Patients undergo low-dose radiotherapy once daily on days 1-5, 8-12, 15, and 16.

In both arms, treatment continues in the absence of disease progression or unacceptable toxicity.

After completion of study therapy, patients are followed periodically for 5 years and then annually thereafter.

Peer Reviewed and Funded or Endorsed by Cancer Research UK

PROJECTED ACCRUAL: A total of 650 patients will be accrued for this study.

Study Design

Allocation: Randomized, Control: Active Control, Primary Purpose: Treatment




radiation therapy


Cancer Research UK and University College London Cancer Trials Centre
United Kingdom




National Cancer Institute (NCI)

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:45:23-0400

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