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Low-Dose Radiation Therapy in Treating Patients With Follicular Non-Hodgkin's Lymphoma

2014-08-27 03:45:23 | BioPortfolio

Summary

RATIONALE: Radiation therapy uses high-energy x-rays to kill cancer cells. It is not yet known which regimen of low-dose radiation therapy is more effective in treating follicular non-Hodgkin's lymphoma.

PURPOSE: This randomized phase III trial is studying two different regimens of low-dose radiation therapy to compare how well they work in treating patients with follicular non-Hodgkin's lymphoma.

Description

OBJECTIVES:

Primary

- Compare the local progression-free interval in patients with follicular non-Hodgkin's lymphoma (NHL) treated with 2 different regimens of low-dose radiotherapy.

Secondary

- Compare acute toxicity at 4 weeks in patients treated with these regimens.

- Compare late toxicity in patients treated with these regimens.

- Compare tumor response at 12 weeks in patients treated with these regimens.

- Compare overall survival in patients treated with these regimens.

- Assess the health economics of these regimens in these patients.

OUTLINE: This is a multicenter, randomized study. Patients are randomized to one of two treatment arms.

- Arm I : Patients undergo low-dose radiotherapy once daily on days 1 and 2.

- Arm II : Patients undergo low-dose radiotherapy once daily on days 1-5, 8-12, 15, and 16.

In both arms, treatment continues in the absence of disease progression or unacceptable toxicity.

After completion of study therapy, patients are followed periodically for 5 years and then annually thereafter.

Peer Reviewed and Funded or Endorsed by Cancer Research UK

PROJECTED ACCRUAL: A total of 650 patients will be accrued for this study.

Study Design

Allocation: Randomized, Control: Active Control, Primary Purpose: Treatment

Conditions

Lymphoma

Intervention

radiation therapy

Location

Cancer Research UK and University College London Cancer Trials Centre
London
England
United Kingdom
W1T 4TJ

Status

Recruiting

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:45:23-0400

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