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Safety and Efficacy of Recombinant Birch Pollen Allergen in the Treatment of Allergic Rhinoconjunctivitis

2014-07-23 21:45:25 | BioPortfolio

Summary

Safety and efficacy of recombinant birch pollen allergen in the treatment of allergic rhinoconjunctivitis

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Conditions

Birch Pollen Allergy

Intervention

Recombinant birch pollen

Location

Allergopharma Joachim Ganzer KG
Reinbek
Germany
21465

Status

Active, not recruiting

Source

Allergopharma Joachim Ganzer KG

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:45:25-0400

Clinical Trials [360 Associated Clinical Trials listed on BioPortfolio]

Analysis of Immunological Reactions to Foods in Birch Pollen-Allergic Patients

A high number of birch pollen-allergic individuals develop hypersensitivity reactions to certain foods, e.g. apples. This food allergy is due to immunological cross-reactivity. Birch polle...

SUBLIVAC FIX Birch Phase III Short-term Efficacy

The aim of this phase III study is to asses if SUBLIVAC FIX Birch is safe and effective in reducing birch allergy induced symptoms and birch allergy medication usage.

Safety and Efficacy of Specific Immunotherapy With an Aluminium Hydroxide-Adsorbed Allergoid Preparation of Birch Pollen Allergens

This study is an evaluation of the safety and efficacy of specific immunotherapy with a birch pollen allergoid.

Efficacy and Safety of Subcutaneous Immunotherapy in Birch Pollen Allergic Patients

To compare versus placebo the efficacy and safety of recombinant Bet v1, natural purified Bet v1 and birch pollen licenced extract used for subcutaneous immunotherapy.

Efficacy and Safety Trial of SLITone(TM) Birch in Subjects With Hayfever

The trial is performed to assess the efficacy and safety of SLIT One birch for treatment of birch pollen induced allergy

PubMed Articles [1384 Associated PubMed Articles listed on BioPortfolio]

New EAACI definition on pollen season mirrors symptom load for grass and birch pollen-induced allergic rhinitis.

The use of allergen immunotherapy (AIT) for allergic rhinitis and its clinical efficacy in clinical trials depends on the effective determination of pollen allergens exposure time-periods. We evaluate...

Context matters: Th2 polarization resulting from pollen composition and not from protein-intrinsic allergenicity.

In contrast to the pollen context, the major allergen Bet v 1 alone is not responsible for Th2 polarization in allergic sensitization. These findings are highly relevant for birch pollen allergy proph...

Uptake of ozone and modification of lipids in Betula Pendula pollen.

Pollen allergy risk is modified by air pollutants, including ozone, but the chemical modifications induced on pollen grains are poorly understood. Pollen lipidic extract has been shown to act as an ad...

The Incidence of Delayed-Type Hypersensitivity Reactions to Apples Among Patients Allergic to Birch Pollen.

The major apple allergen Mal d 1 cross-reacts with the homologous birch pollen allergen Bet v 1 and causes immunoglobulin E (IgE)-mediated immediate-type allergic reactions. In some patients, delayed-...

Does clinical outcome of birch pollen immunotherapy relate to induction of blocking antibodies preventing IgE from allergen binding? A pilot study monitoring responses during first year of AIT.

The clinical benefit of allergen-specific immunotherapy (AIT) involves induction of blocking antibodies. It is not clear if these antibodies function via steric hindrance alone or a combination of lev...

Medical and Biotech [MESH] Definitions

A growth from a pollen grain down into the flower style which allows two sperm to pass, one to the ovum within the ovule, and the other to the central cell of the ovule to produce endosperm of SEEDS.

Order of dicotyledonous flowering plants in the superorder ROSANAE, and class MAGNOLIOPSIDA. They include birch, beech, bayberry, and walnut species.

A plant genus of the family BETULACEAE that is distinguished from birch (BETULA) by its usually stalked winter buds and by cones that remain on the branches after the small, winged nutlets are released.

Abscission-accelerating plant growth substance isolated from young cotton fruit, leaves of sycamore, birch, and other plants, and from potatoes, lemons, avocados, and other fruits.

The fertilizing element of plants that contains the male GAMETOPHYTES.

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The term allergy is used to describe a response, within the body, to a substance, which is not necessarily harmful in itself, but results in an immune response and a reaction that causes symptoms and disease in a predisposed person, which in turn can cau...


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