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Evaluation of Fibrin Sealant 2 in Retroperitoneal or Intra-Abdominal Surgery

2014-08-27 03:45:29 | BioPortfolio

Summary

A comparison of fibrin sealant 2 versus Surgicel® as an addition to standard surgical practice in stopping mild to moderate soft tissue bleeding during retroperitoneal or intra-abdominal surgery.

Description

The time it will take to stop bleeding will be measured and compared between patients who are treated with fibrin sealant 2 to those who are treated with Surgicel®.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Blood Loss, Surgical

Intervention

Fibrin Sealant 2 (FS2), Oxidized Regenerated Cellulose (Surgicel)

Location

Children's Hospital of Los Angeles
Los Angeles
California
United States
90027

Status

Completed

Source

Ethicon, Inc.

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:45:29-0400

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Medical and Biotech [MESH] Definitions

A cellulose of varied carboxyl content retaining the fibrous structure. It is used as a local hemostatic and as a matrix for normal blood coagulation.

Agents that affect the function of FIBRIN in BLOOD COAGULATION. They used as COAGULANTS for HEMORRHAGE or ANTICOAGULANTS for THROMBOSIS.

A generic name for film produced from wood pulp by the viscose process. It is a thin, transparent sheeting of regenerated cellulose, moisture-proof and sometimes dyed, and used chiefly as food wrapping or as bags for dialysis. (Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A fibrin matrix derived from platelet-rich plasma that contains high concentration of BLOOD PLATELETS; LEUKOCYTES; CYTOKINES; and GROWTH FACTORS. It is used in a variety of clinical and TISSUE ENGINEERING applications.

A type of ion exchange chromatography using diethylaminoethyl cellulose (DEAE-CELLULOSE) as a positively charged resin. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

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