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Effect of an Immunotoxin on Activated Human Macrophages in Those With Allergic Rhinitis or Mild Intermittent Asthma

2014-07-23 21:46:04 | BioPortfolio

Summary

The primary objective of this study is to isolate macrophages by using bronchoalveolar lavage (BAL) for different in vitro experiments.

Therefore, following a baseline BAL, allergen, endotoxin, and saline will be instilled into three different lung segments during the first bronchoscopy. After 24 hours during a second bronchoscopy, BAL fluid will be collected in these challenged segments to harvest invaded cells for in vitro experimentation. In addition, segmental bronchial biopsies will be taken to assess the degree of local inflammation.

Study Design

Allocation: Non-Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label

Conditions

Atopy

Intervention

bronchoscopy, allergen/endotoxin instillation

Location

Fraunhofer ITEM
Hannover
Germany
30625

Status

Terminated

Source

Fraunhofer-Institute of Toxicology and Experimental Medicine

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:46:04-0400

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Medical and Biotech [MESH] Definitions

Sensitive method for detection of bacterial endotoxins and endotoxin-like substances that depends on the in vitro gelation of Limulus amebocyte lysate (LAL), prepared from the circulating blood (amebocytes) of the horseshoe crab, by the endotoxin or related compound. Used for detection of endotoxin in body fluids and parenteral pharmaceuticals.

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