Inspiratory Muscle Training in Hypercapnic COPD

2014-07-23 21:46:13 | BioPortfolio


The trial intends to investigate, whether inspiratory muscle training in hypercapnic patients improves inspiratory muscle strength, inspiratory muscle endurance and endurance to walk within six minutes.


Inspiratory muscle training is known to improve inspiratory muscle strength, inspiratory muscle endurance and walking distance within six minutes in patients with neuromuscular and thoraco-restrictive disease as well as in patients with COPD. Studies have only been conducted in patients without established respiratory failure. COPD patients with respiratory failure though are characterized by higher work rates of the inspiratory muscles and higher esophageal pressure swings compared to non-hypercapnic patients indication a discrepancy between muscle load and muscle capabilities. Therefore we hypothesize that for these patients training of their inspiratory muscles will be of benefit in terms of improvement of muscular and whole body endurance.

During this investigation inspiratory muscle training will be applied in a randomized controlled fashion in 40 patients over a period of four weeks parallel to physical rehabilitation.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind, Primary Purpose: Treatment




inspiratory muscle training


Fachkrankenhaus Kloster Grafschaft




Krankenhaus Kloster Grafschaft

Results (where available)

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Published on BioPortfolio: 2014-07-23T21:46:13-0400

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PubMed Articles [6751 Associated PubMed Articles listed on BioPortfolio]

Effects of inspiratory muscle training in COPD patients: A systematic review and meta-analysis.

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Medical and Biotech [MESH] Definitions

The maximum volume of air that can be inspired after reaching the end of a normal, quiet expiration. It is the sum of the TIDAL VOLUME and the INSPIRATORY RESERVE VOLUME. Common abbreviation is IC.

The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.

Financial support for training including both student stipends and loans and training grants to institutions.

Technique based on muscle relaxation during self-hypnotic exercises. It is used in conjunction with psychotherapy.

A variety of techniques used to help individuals utilize their voice for various purposes and with minimal use of muscle energy.

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