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Positron Emission Tomography Using Fluorothymidine F 18 in Finding Recurrent Disease in Patients With Gliomas

2014-08-27 03:46:44 | BioPortfolio

Summary

RATIONALE: Diagnostic procedures, such as positron emission tomography using fluorothymidine F 18, may be effective in finding recurrent disease in patients with gliomas.

PURPOSE: This clinical trial is studying how well positron emission tomography using fluorothymidine F 18 works in finding recurrent disease in patients with gliomas.

Description

OBJECTIVES:

Primary

- Determine the safety of fluorothymidine F 18 for visual and dynamic brain tumor images in patients with glial neoplasms.

- Determine, preliminarily, the efficacy of this drug.

Secondary

- Compare, preliminarily, the efficacy of this drug to fludeoxyglucose F 18 in differentiating tumor recurrence from radiation necrosis.

- Determine the optimal time to image post injection of this drug.

OUTLINE: This is a pilot, nonrandomized study.

Patients receive fluorothymidine F 18 IV over 1 minute and then undergo positron emission tomography (PET) scanning of the brain over 2 hours.

After completion of the PET scan, patients are followed for at least 1 month.

PROJECTED ACCRUAL: A total of 12 patients will be accrued for this study.

Study Design

Allocation: Non-Randomized, Primary Purpose: Diagnostic

Conditions

Brain and Central Nervous System Tumors

Intervention

3'-deoxy-3'-[18F]fluorothymidine, positron emission tomography

Location

University Cancer Center at University of Washington Medical Center
Seattle
Washington
United States
98195-6043

Status

Completed

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:46:44-0400

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Medical and Biotech [MESH] Definitions

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