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The Effect of Vitamin D on Bone Accretion and Turn-Over in Young Girls

2014-08-27 03:47:05 | BioPortfolio

Summary

Objectives To evaluate the effect of increased vitamin D intake on vitamin D status, bone mass and bone turnover in young girls aged 12-13.

More specifically the effects on the following parameters will be assessed:

- Vitamin D metabolites.

- Parathyroid hormone.

- Bone turnover.

- Bone mineral accretion.

- Serum calcium and phosphate.

- Renal handling of calcium and phosphate.

Description

This work package will consist of a randomised double blind one-year vitamin D supplementation study. Primary effect parameter is change in bone mineral content and therefore study duration will be one year. A total of 225 subjects, 75 in each of the three groups: one control and two intervention groups, will be included Two dosages of supplementation will be used: 5 µg per day and 10 µg per day.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Prevention

Conditions

Vitamin D Deficiency

Intervention

cholecalciferol (D3) (vitamin)

Location

Department of Human Nutrition, The Royal Veterinary and Agricultural University
Frederiksberg
Denmark
DK 1958

Status

Completed

Source

University of Copenhagen

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:47:05-0400

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A cytochrome P-450 enzyme that has specificity for CHOLECALCIFEROL (Vitamin D3). It hydroxylates the molecule at carbon position 24.

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