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Efficacy and Safety of Roflumilast in Japanese Patients With Bronchial Asthma (20 to 70 y) (APTA-2217-05)

2014-07-23 21:47:21 | BioPortfolio

Summary

The aim of the study is to investigate the effect of roflumilast (APTA-2217) on lung function in patients with asthma. Roflumilast will be administered orally once daily. The study duration consists of a baseline period (2 to 4 weeks) and a treatment period (24 weeks). The study will provide further data on safety, tolerability, and effectiveness of roflumilast.

Study Design

Allocation: Randomized, Control: Placebo Control, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Conditions

Bronchial Asthma

Intervention

Roflumilast

Location

Nycomed Japan and Mitsubishi Tanabe Pharma Corporation
Osaka
Japan

Status

Completed

Source

ALTANA Pharma

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:47:21-0400

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Long-Term Study of Safety and Efficacy of Roflumilast in Japanese Patients With Bronchial Asthma (20 to 71 y) (APTA-2217-07)

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PubMed Articles [1180 Associated PubMed Articles listed on BioPortfolio]

The sensitivity and specificity of the mannitol bronchial challenge test to identify asthma in different populations: a systematic review.

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Improvement of asthma control after laser acupuncture and its impact on exhaled 8-isoprostane as an oxidative biomarker in chronic bronchial asthma.

Traditional medicine may not control bronchial asthma. Many patients have uncontrolled symptoms and the underlying ongoing inflammation is persistent.

The Suppressive Role of Streptococcus pneumoniae Colonization in Acute Exacerbations of Childhood Bronchial Asthma.

Little is known about the association between bacterial infections and exacerbations of bronchial asthma.

NONSPECIFIC SENSITIVITY OF THE BRONCHES IN PATIENTS WITH BRONCHIAL ASTHMA AND RESPIRATORY ASYMPTOMATIC CHILDREN.

The aim of our study was a comparative description of the state of bronchial sensitivity to nonspecific stimuli in respiratory asymptomatic children and children with bronchial asthma. We investigated...

Serum levels of IL-5, IL-6, IL-8, IL-13 and IL-17A in pre-defined groups of adult patients with moderate and severe bronchial asthma.

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Medical and Biotech [MESH] Definitions

Thermal destruction of the excess bronchial SMOOTH MUSCLE tissue with heat delivered through a catheter assembly attached to a BRONCHOSCOPE. It is often used to control BRONCHIAL HYPERREACTIVITY in severe ASTHMA for better AIRWAY MANAGEMENT.

A beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM.

A histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.

A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It's most common use is in bronchial asthma, but it has been investigated for several other applications.

Left bronchial arteries arise from the thoracic aorta, the right from the first aortic intercostal or the upper left bronchial artery; they supply the bronchi and the lower trachea.

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