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Higher Dose of Ramipril Versus Addition of Telmisartan-Ramipril in Hypertension and Diabetes

2014-08-27 03:49:24 | BioPortfolio

Summary

The purpose of this study is to determine if a dose of ramipril combined with a normal dose of telmisartan 80 mg will be more effective than ramipril 20 mg in reducing microalbuminuria in hypertensive patients with diabetes.

Description

The purpose of this study is to determine the effects of ramipril 10 mg and telmisartan 80 mg versus ramipril 20 mg in patients with diabetes type II, hypertension and microalbuminuria (Urinary-albuminuria creatinine ratio of 2.0 to 25 mg/mmol) on

1. Microalbuminuria

2. Blood pressure (systolic, diastolic and ABPM), Renin-angiotensin system, Catecholamines, Oxydative stress

3. Comparison at 4, 8 and 12 weeks with addition of hydrochlorothiazide 12.5 mg if BP over 130/80 mmHg

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Hypertension

Intervention

ramipril, ramipril-telmisartan

Location

Institut de Recherches Cliniques de Montreal
Montreal
Quebec
Canada
J4X 1J3

Status

Terminated

Source

Institut de Recherches Cliniques de Montreal

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:49:24-0400

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