Effectiveness of a Low Carbohydrate Diet Versus a High Carbohydrate Diet in Promoting Weight Loss and Improved Health

2014-08-27 03:49:43 | BioPortfolio


This study will examine the effects of a low carbohydrate diet versus a high carbohydrate diet on weight loss.


The number of overweight and obese Americans has increased significantly in recent years. There are now many different diet plans being promoted by doctors and the media. The Atkins diet, a low carbohydrate nutritional plan, is especially popular; its advocates claim that following the diet will result in long-term weight loss with no negative effects. Another diet, called the Dietary Approaches to Stop Hypertension (DASH) diet, is a high carbohydrate diet designed to help treat and prevent high blood pressure. However, more thorough investigation of these claims is needed. This study will compare the short- and long-term effects of the Atkins diet to the (DASH) diet. This trial will enroll overweight and obese participants.

This study will last 30 months and will comprise two phases. Participants will be randomly assigned to either the Atkins or DASH diet for 30 months. During Phase 1, all participants will undergo 6 months of weekly group therapy to encourage weight loss. Phase 2 is a weight loss maintenance phase. During Phase 2, participants will have monthly meetings with a therapist for weight loss support. Study visits will occur at study entry and at Months 3 and 30. At each study visit, weight measurements, blood and urine collection, and x-rays will occur to determine participants' weight loss, cardiovascular health, kidney function, and bone density.

Study Design

Allocation: Randomized, Control: Uncontrolled, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment




Atkins diet (low carbohydrate diet), Dietary Approaches to Stop Hypertension (DASH) diet (high carbohydrate diet)


Kaiser Permanente Center for Health Research
United States


Active, not recruiting


National Center for Complementary and Alternative Medicine (NCCAM)

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:49:43-0400

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Medical and Biotech [MESH] Definitions


A diet that contains limited amounts of CARBOHYDRATES. This is in distinction to a regular DIET.

Dietary recommendations that promote reduction in or prevention of high blood pressure. Recommendations include increasing intake of fruits and vegetables, and high-fiber, low-fat foods and reducing the intake of DIETARY SODIUM and high fat foods.

A diet prescribed in the treatment of diabetes mellitus, usually limited in the amount of sugar or readily available carbohydrate. (Dorland, 27th ed)

Dietary practice of completely avoiding meat products in their DIET, consuming vegetables, grains, and nuts. Some who are called lacto-ovo also include milk and egg products.

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