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Biobank Meningioma: Storing Blood for Analysis of DNA and Protein of Patients With Meningioma

2014-08-27 03:50:27 | BioPortfolio

Summary

The purpose of this study is to determine, by means of DNA and protein analysis, the relationship between DNA and protein profiles and a number of endpoints which are important for the patient such as overall survival and side effects.

Description

It has already been known for a long time that cancer is a genetic disorder and that the development of the illness is a very complex interaction between genetic and surrounding factors. Also the response on therapy and the development and seriousness of side effects is stipulated by this complicated collaboration of genetic and surrounding factors. Moreover it is not only the DNA that plays an important role but also the systems of control at protein level. At this moment a lot of questions remain to be answered because up till now the studies were of rather restricted statistical strength with frequently inconsistent dates and moreover retrospective. Major retrospective studies are necessary to distinguish the relationship between DNA/protein patterns and clinical relevant endpoints like prognosis and toxicity in which an as broad as possible patient group is being monitored. For this reason we want to take blood samples in MAASTRO clinic of all patients with meningioma and store it encrypted so that we can perform DNA and protein analyses in future and to correlate the results with survival and toxicity of the treatment.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Meningioma

Status

Withdrawn

Source

Maastricht Radiation Oncology

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:50:27-0400

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Mifepristone in Meningioma

To compare daily oral mifepristone vs placebo with respect to time to treatment failure in patients with unresectable meningioma.

Phase II Trial of Pembrolizumab in Recurrent or Residual High Grade Meningioma

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Trial of the Combination of Bevacizumab and Everolimus in Patients With Refractory, Progressive Intracranial Meningioma

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Monthly SOM230C for Recurrent or Progressive Meningioma

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Imatinib Mesylate in Treating Patients With Recurrent Malignant Glioma or Meningioma

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PubMed Articles [79 Associated PubMed Articles listed on BioPortfolio]

Expression, correlation and prognostic significance of CD133, P57 and HSF1 in meningioma.

The present study investigated the expressions of CD133, P57 and HSF1 in meningioma so as to explore their protagonists in the prognosis of meningioma.

Comprehensive Molecular Profiling Identifies FOXM1 as a Key Transcription Factor for Meningioma Proliferation.

Meningioma is the most common primary intracranial tumor, but the molecular drivers of aggressive meningioma are incompletely understood. Using 280 human meningioma samples and RNA sequencing, immunoh...

Lung metastases from intracranial bleeding meningioma: A case report.

Meningioma is slow-growing benign neoplasm that derived from the meningothelial cells of the arachnoid mater, and it is the most common type of primary brain tumor. Although cases of extracranial meta...

Primary Intraosseous Lymphoplasmacyte-Rich Meningioma: A Case Report.

Lymphoplasmacyte-rich meningioma is an uncommon variant of meningioma, and that arising in the extradural site is extremely rare. Herein, we report a case of primary intraosseous lymphoplasmacyte-rich...

The curative effect analysis of unilateral subfrontal combined with interhemispheric approach on the microsurgery of large anterior skull base meningioma.

To explore the surgical technique and curative effect of microsurgical resection of large anterior skull base meningioma via unilateral subfrontal and interhemispheric approach.The clinical data of 14...

Medical and Biotech [MESH] Definitions

A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)

Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.

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