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The Use of Zoledronic Acid to Prevent Cancer-treatment Bone Loss in Post-menopausal Women Receiving Adjuvant Letrozole for Breast Cancer

2014-08-27 03:50:52 | BioPortfolio

Summary

Post-menopausal breast cancer patients will receive letrozole daily and will be randomized between upfront zoledronic acid or delayed start zoledronic acid. Delayed start zoledronic will be initiated when either the BMD T-score is below -2 SD at either the lumbar spine or hip or any clinical fracture unrelated to trauma or an asymptomatic fracture discovered at the month 36 scheduled visit. Letrozole will be given daily for 5 years. Zoledronic acid will be given every six months. The duration of therapy will be the same as letrozole. The onset will be as previously described.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Breast Cancer

Intervention

zoledronic acid

Status

Completed

Source

Novartis

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:50:52-0400

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