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Determining the Prevalence of HIV-Related Neurological Disorders in the Asia Pacific

2014-08-27 03:50:58 | BioPortfolio

Summary

This study will determine the prevalence of HIV-related neurological disorders in the countries of the Asia-Pacific Region.

Description

This a cross-sectional study to determine the prevalence of HIV-related Neurological Disorders in the countries of the Asia-Pacific Region. Researchers will visit each country site for a period of 2-3 weeks and work with local investigators. Outpatients will be evaluated once-only for the presence of HIV-related symptomatic peripheral neuropathy and HIV-related Neurocognitive Impairment. Inpatients at the sites will be evaluated once-only for the presence of HIV dementia, cerebral toxoplasmosis, cerebral tuberculosis, cryptococcal meningitis, lymphoma, PML and CMV encephalitis.

The Primary outcomes are:

1. To determine the prevalence of HIV-related neurocognitive impairment and ADC at the APNAC-10 sites

2. To determine the prevalence of symptomatic peripheral sensory neuropathy at the APNAC-10 sites

3. To determine the prevalence of central nervous system opportunistic infections and tumours at the APNAC-10 sites

The secondary outcomes are:

To determine the degree of cognitive impairment in patients presenting with HIV-related cognitive impairment at the APNAC-10 sites

- To determine the CD4 cell counts, HIV viral loads HIV viral loads and prior AIDS defining illnesses (ADIs) of patients presenting with HIV-related neurocognitive impairment and ADC at the APNAC-10 sites

- To compare the prevalence of HIV-related neurocognitive impairment and ADC at the APNAC-10 sites to the published pre-HAART prevalence of these conditions in developed countries

- To compare the prevalence of HIV-related neurocognitive impairment and ADC between the APNAC-10 sites

- To describe the severity of symptoms of patients presenting with symptomatic peripheral sensory neuropathy at the APNAC-10 sites

- To determine the CD4 cell counts, HIV viral loads HIV viral loads and prior ADIs of patients presenting with symptomatic peripheral sensory neuropathy at the APNAC-10 sites

- To determine what proportion of symptomatic peripheral sensory neuropathy may be ascribed to HIV alone, to the use of nucleoside analogues

- To compare the prevalence of symptomatic peripheral sensory neuropathy at the APNAC-10 sites to the published pre-HAART prevalence of these conditions in developed countries

- To compare the prevalence of symptomatic peripheral sensory neuropathy between the APNAC-10 sites

- To determine the prevalence of asymptomatic peripheral neuropathy

- To describe the presenting symptoms and signs of patients presenting with CNS OIs and tumours at the APNAC-10 sites

- To describe the neuroradiological findings of patients presenting with CNS OIs and tumours at the APNAC-10 sites

- To determine the serological, culture and other diagnostic test results of patients presenting with CNS OIs and tumours at the APNAC-10 sites

- To determine the CD4 cell counts, HIV viral loads and prior ADIs of patients presenting with CNS OIs and tumours at the APNAC-10 sites

- To compare the prevalence of CNS OIs and tumours at the APNAC-10 sites to the published pre-HAART prevalence of these conditions in developed countries

- To compare the prevalence of CNS OIs and tumours between the APNAC-10 sites

Study Design

Additional Descriptors: Convenience Sample, Observational Model: Natural History, Time Perspective: Cross-Sectional, Time Perspective: Prospective

Conditions

HIV Infections

Location

Alfred Hospital
Melbourne
Victoria
Australia
3004

Status

Active, not recruiting

Source

National Institute of Mental Health (NIMH)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:50:58-0400

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