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The Pain Pen for Breakthrough Cancer Pain

2014-08-27 03:52:42 | BioPortfolio

Summary

The purpose of this study is to see whether injection of hydromorphone through a subcutaneous injection device is more effective in treating breakthrough cancer pain than oral morphine.

Description

Breakthrough pain is an exacerbation of severe pain that occurs on a background of otherwise controlled pain. Breakthrough pain is common in patients with advanced cancer. Current medications to treat breakthrough pain include oral immediate release opioid formulations and more recently oral transmucosal fentanyl citrate.

The pain pen study is a randomized controlled double blind cross-over study comparing the efficacy of oral immediate release morphine with that of subcutaneous hydromorphone, injected through a so called pain pen, on breakthrough pain in cancer patients. Preliminary experience with the pain pen suggests that it has a more rapid time of onset of pain relief than oral formulations.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Neoplasms

Intervention

Subcutaneous hydromorphone delivered by pain pen

Location

Dept. Neurology, Erasmus MC
Rotterdam
Netherlands
3015 GD

Status

Terminated

Source

Erasmus Medical Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:52:42-0400

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PubMed Articles [6053 Associated PubMed Articles listed on BioPortfolio]

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Medical and Biotech [MESH] Definitions

Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.

A collective term for precoordinated organ/neoplasm headings locating neoplasms by organ, as BRAIN NEOPLASMS; DUODENAL NEOPLASMS; LIVER NEOPLASMS; etc.

A type of pain that is perceived in an area away from the site where the pain arises, such as facial pain caused by lesion of the VAGUS NERVE, or throat problem generating referred pain in the ear.

Presence of air or gas in the subcutaneous tissues of the body.

The uptake of substances via the SUBCUTANEOUS TISSUE.

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