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The Pain Pen for Breakthrough Cancer Pain

2014-08-27 03:52:42 | BioPortfolio

Summary

The purpose of this study is to see whether injection of hydromorphone through a subcutaneous injection device is more effective in treating breakthrough cancer pain than oral morphine.

Description

Breakthrough pain is an exacerbation of severe pain that occurs on a background of otherwise controlled pain. Breakthrough pain is common in patients with advanced cancer. Current medications to treat breakthrough pain include oral immediate release opioid formulations and more recently oral transmucosal fentanyl citrate.

The pain pen study is a randomized controlled double blind cross-over study comparing the efficacy of oral immediate release morphine with that of subcutaneous hydromorphone, injected through a so called pain pen, on breakthrough pain in cancer patients. Preliminary experience with the pain pen suggests that it has a more rapid time of onset of pain relief than oral formulations.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Neoplasms

Intervention

Subcutaneous hydromorphone delivered by pain pen

Location

Dept. Neurology, Erasmus MC
Rotterdam
Netherlands
3015 GD

Status

Terminated

Source

Erasmus Medical Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:52:42-0400

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Safety Study of Intravenous Hydromorphone Using Incremental 1mg Doses up to 2mg for Adult ED Patients

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PCA vs Non-PCA Intravenous Hydromorphone Titration for Severe Cancer Pain

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The purpose of this study was to characterize a safe and effective means of conversion and titration to an appropriate dose of hydromorphone HCI, to demonstrate comparable efficacy of OROS...

A Study of OROS Hydromorphone HCL vs Morphine in Cancer Pain Patients.

The purpose of this study was to demonstrate the clinical equivalence of hydromorphone and morphine (immediate-release [IR] and sustained-release [SR] formulations) using the "worst pain i...

PubMed Articles [6101 Associated PubMed Articles listed on BioPortfolio]

Sustained-Release Hydromorphone Microparticles Produced by Supercritical Fluid Polymer Encapsulation.

Chronic cancer pain remains prevalent and severe for many patients, particularly in those with advanced disease. The effectiveness of analgesic/adjuvant drug treatments in routine practice has changed...

Characteristics of Glutamate-Evoked Pain in the Masseter Region: Differences Between Targeted Injections in Subcutaneous, Muscle, and Bone Tissues.

To investigate whether glutamate-evoked pain in the masseter region differs between three different depths of injection, targeting subcutaneous, muscle, and bone tissues.

Subcutaneous or intravenous opioid administration by patient-controlled analgesia in cancer pain: a systematic literature review.

Opioids administered by various routes are a mainstay of tumour-related pain management. Subcutaneous or intravenous patient-controlled analgesia (PCA) with opioids is an appropriate and safe form of ...

Twelve-month effect of chronic pain self-management intervention delivered in an easily accessible primary healthcare service - a randomised controlled trial.

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Trends in and predictors of hydromorphone administration in US emergency departments (2007-2014).

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Medical and Biotech [MESH] Definitions

Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.

A collective term for precoordinated organ/neoplasm headings locating neoplasms by organ, as BRAIN NEOPLASMS; DUODENAL NEOPLASMS; LIVER NEOPLASMS; etc.

A type of pain that is perceived in an area away from the site where the pain arises, such as facial pain caused by lesion of the VAGUS NERVE, or throat problem generating referred pain in the ear.

The uptake of substances via the SUBCUTANEOUS TISSUE.

Presence of air or gas in the subcutaneous tissues of the body.

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