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RATIONALE: Drugs used in chemotherapy, such as 17-AAG, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Determine the 1-year treatment failure rate in patients with inoperable locoregionally advanced or metastatic medullary or differentiated thyroid carcinoma treated with 17-N-allylamino-17-demethoxygeldanamycin (17-AAG).
- Determine the toxicity of this drug in these patients.
- Determine the 1-year progression-free rate in patients treated with this drug.
- Determine the response rate and duration of response in patients treated with this drug.
- Determine the time to treatment failure and time to subsequent therapy in patients treated with this drug.
- Determine the time to disease progression and overall survival of patients treated with this drug.
- Correlate the incidence rate of RAS, RAF, and RET mutations with clinical outcome in patients treated with this drug.
OUTLINE: This is a multicenter study. Patients are stratified according to type of thyroid carcinoma (medullary vs differentiated).
Patients receive 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) IV over 2-6 hours on days 1, 4, 8, and 11. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed every 3 months until disease progression and then every 6 months for up to 3 years from study entry.
PROJECTED ACCRUAL: A total of 28-72 patients (14-36 per stratum) will be accrued for this study within 24 months.
Masking: Open Label, Primary Purpose: Treatment
Head and Neck Cancer
Howard University Cancer Center
District of Columbia
Active, not recruiting
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:53:03-0400
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