Topics

Spinal Cord Stimulation to Restore Cough

2015-05-13 18:21:46 | BioPortfolio

Summary

The purpose of this trial is to determine the efficacy of spinal cord stimulation to produce an effective cough in patients with spinal cord injuries.

Description

Patients with cervical and thoracic spinal cord injuries often have paralysis of a major portion of their expiratory muscles — the muscles responsible for coughing — and therefore, lack a normal cough mechanism. Consequently, most of these patients suffer from a markedly reduced ability to clear airway secretions, a factor which contributes to the development of recurrent respiratory tract infections such as pneumonia and bronchitis. Expiratory muscles can be activated by electrical stimulation of the spinal roots to produce a functionally effective cough.

The purpose of this trial is to determine if electrical stimulation of the expiratory muscles is capable of producing an effective cough on demand. According to the trial researchers, if successful, this technique will prevent the need for frequent patient suctioning — which often requires the constant presence of trained personnel. It will also allow spinal cord injured patients to clear their secretions more readily, thereby reducing the incidence of respiratory complications and associated illness and death.

In the trial, researchers will study 18 adults (18-70 years old) with spinal injuries (T5 level or higher), at least 12 months following the date of injury. After an evaluation of medical history, a brief physical examination, and initial testing, participants will have small electrodes (metal discs) placed — by a routine surgical procedure — over the surface of their spinal cords on the lower back to stimulate the expiratory muscles and restore cough.

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Spinal Cord Injuries

Intervention

Spinal Cord Stimulation, Expiratory Muscle Stimulator

Location

MetroHealth Medical Center
Cleveland
Ohio
United States
44109

Status

Active, not recruiting

Source

Case Western Reserve University

Results (where available)

View Results

Links

Published on BioPortfolio: 2015-05-13T18:21:46-0400

Clinical Trials [5751 Associated Clinical Trials listed on BioPortfolio]

Evaluation of Wire Electrodes to Activate the Expiratory Muscles to Restore Cough

Respiratory infections, such as pneumonia and bronchitis, occur frequently in the spinal cord injured population, due to paralysis of the muscles responsible for coughing. Using spinal cor...

Spinal Cord Stimulation Efficacy Measures

The purpose of the study is to measure the efficacy of varying spinal cord stimulation frequencies and pulse-width settings on chronic pain management. The spinal cord stimulator settings...

A High Frequency Spinal Cord Stimulation PET-CT Scan Study

This study aims to investigate the clinical response to Spinal Cord Stimulation frequency parameters: 40Hz, 4000Hz and 10000Hz and explore the brain imaging changes using PET-CT scans. We ...

Patient Experience Comparing Tonic Vs. Burst Spinal Cord Stimulation For Chronic Pain

Researchers are evaluating if subjects who have already experienced tonic spinal cord stimulation would have a better pain relief status with burst spinal cord stimulation.

Efficacy of Spinal Cord Stimulation in Patients With a Failed Back Surgery Syndrome.

When patients suffer from chronic pain after multiple back surgeries, this is denominated as the 'failed back surgery syndrome'. A possible treatment for these patients is spinal cord stim...

PubMed Articles [7706 Associated PubMed Articles listed on BioPortfolio]

Spinal cord stimulation failure: evaluation of factors underlying hardware explantation.

Spinal cord stimulation has been shown to improve pain relief and reduce narcotic analgesic use in cases of complex refractory pain syndromes. However, a subset of patients ultimately undergoes remova...

Bibliometric analysis of scientific publications on spinal cord stimulation in the past two decades.

Spinal cord stimulation (SCS), a common invasive neuromodulation technique, induced pain relief via electrical stimulation of the dorsal column of the spinal cord.

Restoration of cough via spinal cord stimulation improves pulmonary function in tetraplegics.

Spinal cord injury (SCI) results in significant loss in pulmonary function secondary to respiratory muscle paralysis. Retention of secretions and atelectasis and, recurrent respiratory tract infection...

Anatomy of the human spinal cord arachnoid cisterns: applications for spinal cord surgery.

The goal in this study was to describe the overall organization of the spinal arachnoid mater and spinal subarachnoid space (SSAS) as well as its relationship with surrounding structures, in order to ...

Use of in vitro electroporation and slice culture for gene function analysis in the mouse embryonic spinal cord.

The spinal cord is an important part of the central nervous system (CNS). At present, the expression of the exogenous gene in the spinal cord of the embryonic mouse needs in utero spinal cord electrop...

Medical and Biotech [MESH] Definitions

Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimeningeal spaces surrounding the spinal cord. Traumatic injuries, vascular diseases, infections, and inflammatory/autoimmune processes may affect the spinal cord.

Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.

Repair of the damaged neuron function after SPINAL CORD INJURY or SPINAL CORD DISEASES.

Application of electric current to the spine for treatment of a variety of conditions involving innervation from the spinal cord.

Pathological processes involving any of the BLOOD VESSELS feeding the SPINAL CORD, such as the anterior and paired posterior spinal arteries or their many branches. Disease processes may include ATHEROSCLEROSIS; EMBOLISM; and ARTERIOVENOUS MALFORMATIONS leading to ISCHEMIA or HEMORRHAGE into the spinal cord (hematomyelia).

More From BioPortfolio on "Spinal Cord Stimulation to Restore Cough"

Quick Search

Relevant Topics

Spinal Cord Disorders
The spinal cord is a bundle of nerves that runs down the middle of the back which carry signals back and forth between the body and brain. It is protected by vertebrae, which are the bone disks that make up the spine. An accident that damages the verte...

Respiratory
Asthma COPD Cystic Fibrosis Pneumonia Pulmonary Medicine Respiratory Respiratory tract infections (RTIs) are any infection of the sinuses, throat, airways or lungs.  They're usually caused by viruses, but they can also ...

Pulmonary
Pulmonary relating to or associated with the lungs eg Asthma, chronic bronchitis, emphysema, COPD, Cystic Fibrosis, Influenza,  Lung Cancer, Pneumonia, Pulmonary Arterial Hypertension, Sleep Disorders etc Follow and track Lung Cancer News ...


Searches Linking to this Trial