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4-HPR and FTI in Head and Neck Squamous Cell Carcinoma (HNSCC)

2014-08-27 03:53:39 | BioPortfolio

Summary

The primary objective of this study is to estimate the modulation of intermediate biological endpoints of the combination of 4-HPR and SCH66336, a farnesyl transferase inhibitor (FTI), across 4 randomly assigned dose levels in patients with locally advanced or recurrent head and neck cancer. We will also assess the activity, safety, tolerability and side effects of 4-HPR/SCH66336 and hope to establish a phase II regimen.

Study Design

Allocation: Randomized, Control: Dose Comparison, Endpoint Classification: Bio-availability Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Head and Neck Cancer

Intervention

fenretinide (4-HPR), SCH66336

Location

MD Anderson Cancer Center
Houston
Texas
United States
77030

Status

Terminated

Source

M.D. Anderson Cancer Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:53:39-0400

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