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Capecitabine in Treating Patients With Locally Recurrent or Metastatic Nasopharygeal Cancer

2014-08-27 03:53:54 | BioPortfolio

Summary

RATIONALE: Drugs used in chemotherapy, such as capecitabine, work in different ways to stop tumor cells from dividing so they stop growing or die.

PURPOSE: Phase II trial to study the effectiveness of capecitabine in treating patients who have locally recurrent or metastatic nasopharyngeal cancer.

Description

OBJECTIVES:

Primary

- Determine the overall response rate (complete response and partial response) in patients with previously treated recurrent locoregional or metastatic carcinoma of the nasopharynx treated with capecitabine.

Secondary

- Determine median progression-free survival of patients treated with this drug.

- Determine median overall survival of patients treated with this drug.

- Correlate tissue thymidine phosphorylase (TP) levels with response to this drug in these patients.

- Correlate the Epstein-Barr virus (EBV) status of these patients with response to this drug.

- Correlate survival with the EBV status of patients treated with this drug.

- Correlate TP levels with EBV status of patients treated with this drug.

OUTLINE: This is a nonrandomized, multicenter study.

Patients receive oral capecitabine twice daily on days 1-14. Treatment repeats every 21 days.

PROJECTED ACCRUAL: A total of 39 patients will be accrued for this study.

Study Design

Masking: Open Label, Primary Purpose: Treatment

Conditions

Head and Neck Cancer

Intervention

capecitabine

Location

University of Chicago Cancer Research Center
Chicago
Illinois
United States
60637-1470

Status

Active, not recruiting

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:53:54-0400

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