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Development of Human Laboratory Study Model of Cocaine Relapse Prevention II - 1

2014-08-27 03:53:59 | BioPortfolio

Summary

To study of classical conditioning mechanisms associated with arousal, craving and cocaine use.

Description

This is a single-site, double-blind, placebo-controlled crossover study of classical conditioning mechanisms associated with arousal, craving and cocaine use.

Study Design

Control: Placebo Control

Conditions

Cocaine-Related Disorders

Intervention

Cocaine (IV)

Location

University of Texas Health Science Center
San Antonio
Texas
United States
78284

Status

Active, not recruiting

Source

National Institute on Drug Abuse (NIDA)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:53:59-0400

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Medical and Biotech [MESH] Definitions

Disorders related or resulting from use of cocaine.

The purified, alkaloidal, extra-potent form of cocaine. It is smoked (free-based), injected intravenously, and orally ingested. Use of crack results in alterations in function of the cardiovascular system, the autonomic nervous system, the central nervous system, and the gastrointestinal system. The slang term "crack" was derived from the crackling sound made upon igniting of this form of cocaine for smoking.

SMOKING of COCAINE.

An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.

Any of several South American shrubs of the Erythroxylon genus (and family) that yield COCAINE; the leaves are chewed with alum for CNS stimulation.

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