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Cranberry Juice for Treatment of Urinary Tract Infections

2014-08-27 03:54:00 | BioPortfolio

Summary

The purpose of this study is to determine whether daily consumption of cranberry juice lessens the symptoms and prevents the recurrence of urinary tract infections (UTIs). This study will also determine whether drinking cranberry juice for 6 months selects for less virulent bacteria in the rectal, vaginal, and urethral areas.

Description

Participants in this study will be randomly assigned to consume either 8 ounces of cranberry juice or placebo juice twice a day for 6 months. Participants will have follow-up visits at 3 and 6 months, and whenever they experience a symptomatic episode. Urine, vaginal and rectal specimens will be taken at each visit to test for the presence of bacteria that cause urinary tract infections. Participants will complete a questionnaire at study entry, Day 3, Weeks 1 and 2, and monthly thereafter or whenever there is a recurrence of symptoms.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Urinary Tract Infections

Intervention

Cranberry juice, Placebo cranberry juice

Location

University of Michigan
Ann Arbor
Michigan
United States
48109

Status

Recruiting

Source

National Center for Complementary and Alternative Medicine (NCCAM)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:54:00-0400

Clinical Trials [2007 Associated Clinical Trials listed on BioPortfolio]

Identification of the Cranberry Juice Compounds That Prevent Urinary Tract Infections

The purpose of this study is to identify the substances in cranberry juice that make it effective in reducing urinary tract infections (UTIs) in women.

Cranberry Juice for Preventing Bacteria in Urine During Pregnancy

The purpose of this study is to determine the amount of cranberry juice that is most effective in preventing a condition in pregnant women that often leads to urinary tract infections (UTI...

Cranberry Juice for the Prevention of Recurrent Urinary Tract Infections

This study will determine whether cranberry juice is effective in reducing recurrent urinary tract infections (UTIs) in women who have had a UTI within the past year.

Interactions Between Cranberry Juice and Antibiotics Used to Treat Urinary Tract Infections

The purpose of study is to determine whether cranberry juice interacts with antibiotics used to treat urinary tract infections (UTIs).

Effects of Cranberry-Containing Products in Women With Recurrent Urinary Tract Infections (UTIs)

The purpose of this study is to determine the role of cranberry-containing products in preventing urinary tract infections (UTIs).

PubMed Articles [6542 Associated PubMed Articles listed on BioPortfolio]

Cranberry juice decreases disease activity in women with rheumatoid arthritis.

Studies have shown that cranberry (Vaccinium macrocarpon) has antiinflammatory and antioxidant effects; however, to our knowledge, the effects of cranberry juice consumption have not been studied in p...

Propolis potentiates the effect of cranberry (Vaccinium macrocarpon) in reducing the motility and the biofilm formation of uropathogenic Escherichia coli.

One strategy to prevent urinary tract infections is the use of natural products such as cranberry (Vaccinium macrocarpon) and propolis. The objective of this study was to evaluate the impact of these ...

Characterization of Blueberry shock virus, an Emerging Ilarvirus in Cranberry.

Blueberry shock virus (BlShV), an Ilarvirus sp. reported only on blueberry, was associated with scarring, disfigurement, and premature reddening of cranberry fruit. BlShV was detected by triple-antibo...

Effect of Fungicide on Pollen Foraging by Honeybees (Hymenoptera: Apidae) in Cranberry Differs by Fungicide Type.

Honeybees (Apis mellifera Linnaeus) (Hymenoptera: Apidae) play a major role in the pollination of cranberry (Vaccinium macrocarpon; Ericaceae). However, fungicide applications during cranberry bloom m...

Cranberry-derived proanthocyanidins induce a differential transcriptomic response within Candida albicans urinary biofilms.

Candida albicans is one of the most common causes of hospital-acquired urinary tract infections (UTIs). However, azoles are poorly active against biofilms, echinocandins do not achieve clinically usef...

Medical and Biotech [MESH] Definitions

Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.

Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.

A surgical specialty concerned with the study, diagnosis, and treatment of diseases of the urinary tract in both sexes, and the genital tract in the male. Common urological problems include urinary obstruction, URINARY INCONTINENCE, infections, and UROGENITAL NEOPLASMS.

A plant genus in the family CAPRIFOLIACEAE. The common name derives from its traditional use for menstrual cramps. It is a source of viburnine, valerianic acid, vibsanin, and ursolic acid. Note that true cranberry is VACCINIUM MACROCARPON.

A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.

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