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Study of Oral SCIO-469 in Relapsed, Refractory Patients With Multiple Myeloma

2014-07-23 21:51:58 | BioPortfolio

Summary

Scio-469 belongs to a new class of treatment that inhibits p38 MAP kinase. p38 MAPK activation controls the production of a number of factors that play a pathogenic role in the development of multiple myeloma (MM), most prominently IL-6, as well as IL-1, TNF, PGE2, IL-11, VEGF, macrophage inflammatory protein-1 (MIP-1), and RANKL. These factors are produced by MM cells and BMSCs when stimulated by secreted factors or by adherence of MM cells to BMSCs. A cytokine network, in which these factors induce each other in feed forward loops, sets up a perpetuating activated state that supports MM cell growth, survival, resistance to cytotoxic chemotherapy, and the development of osteolytic lesions. Disrupting this network at multiple points through the inhibition of p38 MAPK is thus expected to reduce MM growth and survival, increase sensitivity to cytotoxic agents, and reduce pain and fractures from osteolytic lesions. The main objective of this study is to assess the efficacy of SCIO-469 as monotherapy in relapsed, refractory patients with multiple myeloma (MM), based on response rates.

Study Design

Allocation: Non-Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Multiple Myeloma

Intervention

SCIO-469

Location

University of Arkansas for Medical Science
Little Rock
Arkansas
United States
72205

Status

Active, not recruiting

Source

Scios, Inc.

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:51:58-0400

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This study sought to analyze the clinical features and prognosis of multiple myeloma with isolated extramedullary relapse and with the absence of systemic progression. The clinical features and outcom...

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Medical and Biotech [MESH] Definitions

A rare, aggressive variant of MULTIPLE MYELOMA characterized by the circulation of excessive PLASMA CELLS in the peripheral blood. It can be a primary manifestation of multiple myeloma or develop as a terminal complication during the disease.

Abnormal immunoglobulins characteristic of MULTIPLE MYELOMA.

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A pyrazine and boronic acid derivative that functions as a reversible PROTEASOME INHIBITOR. It is used as an ANTINEOPLASTIC AGENT in the treatment of MULTIPLE MYELOMA and MANTLE CELL LYMPHOMA.

Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).

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