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RATIONALE: Drugs used in chemotherapy, such as CCI-779, work in different ways to stop cancer cells from dividing so they stop growing or die.
- Determine the activity of CCI-779 in patients with relapsed, refractory, or transformed chronic lymphocytic leukemia.
OUTLINE: Patients are stratified according to disease (relapsed or refractory chronic lymphocytic leukemia [CLL] vs transformed CLL).
Patients receive CCI-779 IV over 30 minutes on days 1, 8, 15, and 22. Treatment repeats every 28 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients achieving an objective response may receive 3 consolidation courses of therapy.
PROJECTED ACCRUAL: A total of 25-60 patients (12-36 patients with relapsed or refractory chronic lymphocytic leukemia [CLL] and 13-24 patients with transformed CLL) will be accrued for this study within 40 months.
Masking: Open Label, Primary Purpose: Treatment
M.D. Anderson Cancer Center at University of Texas
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:54:13-0400
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