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A Safety and Effectiveness Study of Vaccine Therapy in Patients With Indolent Lymphoma

2014-08-27 03:54:26 | BioPortfolio

Summary

Primary Objectives:

- To document the efficacy of treatment with autologous lymphoma-derived HSPPC-96 of selected patients with indolent lymphoma. The efficacy endpoints are:

- the rate of complete and partial responses

- the time to progression.

Secondary Objectives:

- To evaluate the safety and tolerability of autologous tumor-derived heat-shock protein peptide complex (HSPPC-96) administered intradermally once weekly for four consecutive weeks, followed by HSPPC-96 administered once every two weeks.

- To evaluate the feasibility of autologous HSPPC-96 preparation from lymphoma specimens.

- To assess approximately the composition of the tissue source of the autologous HSPPC-96 for each patient.

- To study the effect of autologous lymphoma-derived HSPPC-96 vaccine therapy on the expression of Fas ligand and TRAIL death proteins in peripheral blood lymphocytes of patients with indolent lymphoma.

Study Design

Allocation: Non-Randomized, Control: Uncontrolled, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Lymphoma, Follicular

Intervention

autologous human tumor-derived HSPPC-96

Location

M.D. Anderson Cancer Center
Houston
Texas
United States
77030

Status

Completed

Source

Antigenics

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:54:26-0400

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