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Study of SGN-40 in Patients With Refractory or Recurrent Multiple Myeloma

2014-07-23 21:52:06 | BioPortfolio

Summary

The purpose of this study is to determine the safety and activity of SGN-40 in a weekly dosage schedule as a single agent.

Description

This is an open-label, multi-dose, single-arm, phase I, dose-escalation study to define the toxicity profile, maximum tolerated dose (MTD), pharmacokinetics, and antitumor activity of SGN-40 in patients with refractory or recurrent multiple myeloma.

A minimum of three patients will be entered into each dose-level cohort. All patients will receive a dose-loading schedule during the first two weeks. The maximum weekly dose will be 16mg/kg.

Study Design

Control: Uncontrolled, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Multiple Myeloma

Intervention

SGN-40 (anti-huCD40 mAb)

Location

James R. Berenson M.D., Inc.
West Hollywood
California
United States
90069

Status

Completed

Source

Seattle Genetics, Inc.

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:52:06-0400

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