Track topics on Twitter Track topics that are important to you
This study will use magnetic resonance imaging (MRI) to examine which areas of the brain are involved in performing certain cognitive tasks. MRI uses a strong magnetic field and radio waves to produce images of body tissues and organs that provide information about structure and function of tissues.
Healthy normal volunteers between 21 and 40 years of age may be eligible for this study. Candidates must be native English speakers and must be right-handed. They must have no history of nervous system disease or psychiatric disorder. Candidates are screened with questionnaires and a neurological examination.
Participants undergo functional MRI scanning. For this procedure, the subject lies on a stretcher that moves into the scanner - a metal cylinder surrounded by a strong magnetic field. During the scan, he or she is asked to make various decisions about whether words are related or not. Two words are presented visually, separated by a variable time delay. The subject reads both words, decides as quickly and accurately as possible whether the two words are related or not, and indicates the answer by pressing a button. The test takes about 2 hours. When it is completed, the subject completes a written questionnaire concerning his or her experience in the scanner.
Objective: The purpose of the protocol is to extend the structured event complex (SEC) model developed by the principal investigator. Grafman (Grafman, 1995) proposed that action sequences are represented in form of SECs in the human prefrontal cortex (PFC). An SEC is a goal-oriented set of events that is sequentially structured and represents thematic knowledge, morals, abstractions, concepts, social rules, event features, event boundaries, and grammars. There are both temporal and semantic associative relations between subcomponents of SEC knowledge. We will investigate hypotheses regarding the role of different regions within the PFC in processing associative relations. We will also investigate how SECs differing in psychological dimensions such as temporal duration, complexity, and familiarity are represented and activated in the PFC. We will further examine the temporal and semantic organization of SEC subcomponents by investigating how the goal structure of event knowledge is represented and activated in the PFC. Further we will investigate how the temporal location of events within SECs are represented and activated in the PFC. We will also investigate how goals specifying the temporal order and duration of SEC subcomponents are processed within the PFC. Additional objectives are to (1) investigate the neural representation of human emotions and decision-making based on utility estimation; (2) investigate the relationships between cognitive and neural substrates of moral emotions and judgment with those of the SEC model developed by the principal investigator; and (3) probe a new construct of cognitive dimensions incorporating critical explanatory variables in moral emotions and event structure.
Study Population: In seven separate studies, healthy, normal adult volunteers will participate in experiments dealing with different kinds of associative relations in SECs using functional magnetic resonance imaging (fMRI).
Design: The experiments we are conducting will employ within-subject, rapid event-related fMRI designs to determine whether different types of SEC associative and other types of relations are stored in dissociable networks in the PFC. In seven experiments, we hope to automatically activate lexical, event-based and temporally-based associative and other types of relations in SECs.
Outcome Measures: The data collected will consist of accuracy and response time measures of cognitive performance reflecting automatic priming of associative relations and fMRI activation images corresponding to each kind of associative relation, and accuracy and response time measures of cognitive performance reflecting how temporal duration, complexity, and familiarity are represented and activated. Experiments 6 and 7 will also record donation choices made by the subjects. The results gained from this protocol will provide further evidence for modifying, supporting, or rejecting aspects of the SEC model, and will provide further evidence for modifying, supporting, or rejecting aspect of a framework of moral behavior.
National Institutes of Health Clinical Center, 9000 Rockville Pike
National Institutes of Health Clinical Center (CC)
Published on BioPortfolio: 2014-08-27T03:54:38-0400
Healthy Together is a program that promotes the achievement and maintenance of healthy weights in children and their families.
Investigators conducted a pilot feasibility and acceptability randomized controlled trial of a remotely delivered behavioral health coaching program in pregnancy and postpartum.
Absorption, distribution, metabolism, and excretion (ADME) study with 14C in healthy young men.
The purpose of this study is to understand how consuming healthy cookies every day for two weeks will affect different types of fat in the blood. Specifically, the overall goal of this stu...
To assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of IMA-026 administered subcutaneously (SC) or intravenously (IV) in healthy adults.
The American Nurses Association declared 2017 the Year of the Healthy Nurse. In an effort to promote a healthy academic environment, faculty and staff in institutions of higher learning should serve a...
Data on cranial morphology of healthy individuals can be used as the guide in the treatment of cranial deformity. There are many reports analyzing the cranial morphology of healthy children in the pas...
Across Ontario, the Healthy Babies Healthy Children (HBHC) postpartum screening tool is routinely used to identify families with potential risk of negative development outcomes for children.
Few studies have recommended the essential domains of healthy aging and their relevant measurement to assess healthy aging comprehensively. This review is to fill the gap, by conducting a literature r...
Cerebrovascular reactivity (CVR), an important measure of cerebrovascular health in adults, has not been examined in healthy adolescents. Beyond the direct importance of understanding CVR in healthy y...
Healthy People Programs are a set of health objectives to be used by governments, communities, professional organizations, and others to help develop programs to improve health. It builds on initiatives pursued over the past two decades beginning with the 1979 Surgeon General's Report, Healthy People, Healthy People 2000: National Health Promotion and Disease Prevention Objectives, and Healthy People 2010. These established national health objectives and served as the basis for the development of state and community plans. These are administered by the Office of Disease Prevention and Health Promotion (ODPHP). Similar programs are conducted by other national governments.
Governmental guidelines and objectives pertaining to public food supply and nutrition including recommendations for healthy diet and changes in food habits to ensure healthy diet.
Surgical reinnervation of a denervated peripheral target using a healthy donor nerve and/or its proximal stump. The direct connection is usually made to a healthy postlesional distal portion of a non-functioning nerve or implanted directly into denervated muscle or insensitive skin. Nerve sprouts will grow from the transferred nerve into the denervated elements and establish contact between them and the neurons that formerly controlled another area.
Process of evaluating the health of a patient and determining if they are healthy enough for surgery.
Dietary patterns which have been found to be important in reducing disease risk.
Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...
Of all the types of Dementia, Alzheimer's disease is the most common, affecting around 465,000 people in the UK. Neurons in the brain die, becuase 'plaques' and 'tangles' (mis-folded proteins) form in the brain. People with Al...