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Trial of a Novel Fibrinolytic (Alfimeprase) to Clear Thrombosed Vascular Access Devices

2014-08-27 03:54:45 | BioPortfolio

Summary

This trial is for patients with a central venous catheter (a vascular access device) that is not functioning properly (unable to withdraw blood). The trial compares a new blood clot dissolving agent (alfimeprase) against the currently used treatment.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Conditions

Catheters, Indwelling

Intervention

Alfimeprase

Location

Cleveland Clinic Foundation
Cleveland
Ohio
United States

Status

Completed

Source

ARCA Biopharma, Inc.

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:54:45-0400

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Safety and Efficacy Study of Alfimeprase in Subjects With Occluded Central Catheters

The purpose of the study is to compare the safety and effectiveness of alfimeprase to a placebo in restoring function of occluded central catheters.

Safety and Efficacy Study of Alfimeprase in Subjects With Occluded Catheters

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Alfimeprase for Thrombolysis in Acute Peripheral Arterial Occlusion

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PubMed Articles [193 Associated PubMed Articles listed on BioPortfolio]

Indwelling pleural catheters in hepatic hydrothorax: A single-center series of outcomes and complications.

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Urinary tract infection (UTI) is the fourth leading cause of healthcare-associated infections, with approximately 70%-80% being attributed to the inappropriate use of indwelling catheters. In many cas...

Indwelling Tunneled Pleural Catheters for Refractory Hepatic Hydrothorax in Patients with Cirrhosis: A Multicenter Study.

The outcome of indwelling pleural catheter (IPC) use in hepatic hydrothorax (HH) is unclear. This study aimed to review the safety and feasibility of IPC in patients with refractory HH.

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Medical and Biotech [MESH] Definitions

Catheters designed to be left within an organ or passage for an extended period of time.

Catheters inserted into various locations within the heart for diagnostic or therapeutic purposes.

Catheters inserted into the URINARY BLADDER or kidney for therapeutic or diagnostic purposes.

Catheters that are inserted into a large central vein such as a SUBCLAVIAN VEIN or FEMORAL VEIN.

A flexible, tubular device that is used to carry fluids into or from a blood vessel, hollow organ, or body cavity.

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