Trial of a Novel Fibrinolytic (Alfimeprase) to Clear Thrombosed Vascular Access Devices

2014-08-27 03:54:45 | BioPortfolio


This trial is for patients with a central venous catheter (a vascular access device) that is not functioning properly (unable to withdraw blood). The trial compares a new blood clot dissolving agent (alfimeprase) against the currently used treatment.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Treatment


Catheters, Indwelling




Cleveland Clinic Foundation
United States




ARCA Biopharma, Inc.

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:54:45-0400

Clinical Trials [185 Associated Clinical Trials listed on BioPortfolio]

Safety and Efficacy Study of Alfimeprase in Subjects With Occluded Central Catheters

The purpose of the study is to compare the safety and effectiveness of alfimeprase to a placebo in restoring function of occluded central catheters.

Safety and Efficacy Study of Alfimeprase in Subjects With Occluded Catheters

To evaluate the safety profile of alfimeprase as assessed by monitoring of adverse events, serious adverse events and major bleeding events for up to 120 minutes following the instillation...

Indwelling Pleural Catheters Versus Indwelling Pleural Catheters Plus Doxycycline

Indwelling pleural catheters (IPCs) are commonly used to treat pleural effusions (build-up of fluid in the lungs). The goal of this clinical research study is to learn if adding the antibi...

Prevention of Nosocomial E. Coli Infections After Placement of an Indwelling Catheter During Pelvic Surgery: an Evaluation of Cranberry Gel Capsules

Indwelling urinary catheters are a primary site for nosocomial infections. The purpose of this study is to evaluate the anti-adhesive properties of Cranberry type A pro anthocyanidine gel...

Alfimeprase for Thrombolysis in Acute Peripheral Arterial Occlusion

This trial is for patients with acute occlusion of one of the arteries supplying blood to the leg. The trial is designed to determine the safety and activity of a novel clot dissolving (t...

PubMed Articles [179 Associated PubMed Articles listed on BioPortfolio]

Indwelling pleural catheters in hepatic hydrothorax: A single-center series of outcomes and complications.

Treatment of hepatic hydrothorax (HH) generally involves sodium restriction, diuretics, and serial thoracentesis. In more advanced cases, transjugular intrahepatic portosystemic shunt (TIPS) and liver...

Reducing the rate of post-surgical urinary tract infections in orthopedic patients.

Urinary tract infection (UTI) is the fourth leading cause of healthcare-associated infections, with approximately 70%-80% being attributed to the inappropriate use of indwelling catheters. In many cas...

Reducing the local use of indwelling urinary catheters in Wolverhampton.

Nurses' and Physicians' Perceptions of Indwelling Urinary Catheter Practices and Culture in Their Institutions.

Indwelling urinary catheters (IUCs) are commonly used devices in acute care that may lead to catheter-associated urinary tract infections or noninfectious complications. Responsibilities for IUC are u...

The Utility of Ultrasound to Diagnose Tunnel-Tract Infection Related to Indwelling Pleural Catheters.

Indwelling pleural catheter (IPC) infections lead to increased morbidity and treatment failure in patients with chronic recurrent pleural effusions. Ultrasonography is a readily available diagnostic t...

Medical and Biotech [MESH] Definitions

Catheters designed to be left within an organ or passage for an extended period of time.

Catheters inserted into various locations within the heart for diagnostic or therapeutic purposes.

Catheters inserted into the URINARY BLADDER or kidney for therapeutic or diagnostic purposes.

Catheters that are inserted into a large central vein such as a SUBCLAVIAN VEIN or FEMORAL VEIN.

A flexible, tubular device that is used to carry fluids into or from a blood vessel, hollow organ, or body cavity.

More From BioPortfolio on "Trial of a Novel Fibrinolytic (Alfimeprase) to Clear Thrombosed Vascular Access Devices"

Quick Search


Relevant Topic

Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

Searches Linking to this Trial