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Trial of a Novel Fibrinolytic (Alfimeprase) to Clear Thrombosed Vascular Access Devices

2014-08-27 03:54:45 | BioPortfolio

Summary

This trial is for patients with a central venous catheter (a vascular access device) that is not functioning properly (unable to withdraw blood). The trial compares a new blood clot dissolving agent (alfimeprase) against the currently used treatment.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Conditions

Catheters, Indwelling

Intervention

Alfimeprase

Location

Cleveland Clinic Foundation
Cleveland
Ohio
United States

Status

Completed

Source

ARCA Biopharma, Inc.

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:54:45-0400

Clinical Trials [176 Associated Clinical Trials listed on BioPortfolio]

Safety and Efficacy Study of Alfimeprase in Subjects With Occluded Central Catheters

The purpose of the study is to compare the safety and effectiveness of alfimeprase to a placebo in restoring function of occluded central catheters.

Safety and Efficacy Study of Alfimeprase in Subjects With Occluded Catheters

To evaluate the safety profile of alfimeprase as assessed by monitoring of adverse events, serious adverse events and major bleeding events for up to 120 minutes following the instillation...

Indwelling Pleural Catheters Versus Indwelling Pleural Catheters Plus Doxycycline

Indwelling pleural catheters (IPCs) are commonly used to treat pleural effusions (build-up of fluid in the lungs). The goal of this clinical research study is to learn if adding the antibi...

Prevention of Nosocomial E. Coli Infections After Placement of an Indwelling Catheter During Pelvic Surgery: an Evaluation of Cranberry Gel Capsules

Indwelling urinary catheters are a primary site for nosocomial infections. The purpose of this study is to evaluate the anti-adhesive properties of Cranberry type A pro anthocyanidine gel...

Alfimeprase for Thrombolysis in Acute Peripheral Arterial Occlusion

This trial is for patients with acute occlusion of one of the arteries supplying blood to the leg. The trial is designed to determine the safety and activity of a novel clot dissolving (t...

PubMed Articles [181 Associated PubMed Articles listed on BioPortfolio]

Urinary Incontinence and Indwelling Urinary Catheters as Predictors of Death after New-Onset Stroke: A Report of the South London Stroke Register.

To explore the relationship between indwelling urinary catheters (IUCs), urinary incontinence (UI), and death in the poststroke period and to determine when, after the neurological event, UI has the b...

Reducing the local use of indwelling urinary catheters in Wolverhampton.

The Utility of Ultrasound to Diagnose Tunnel-Tract Infection Related to Indwelling Pleural Catheters.

Indwelling pleural catheter (IPC) infections lead to increased morbidity and treatment failure in patients with chronic recurrent pleural effusions. Ultrasonography is a readily available diagnostic t...

Outpatient Talc Administration by Indwelling Pleural Catheter for Malignant Effusion.

Background Malignant pleural effusion affects more than 750,000 persons each year across Europe and the United States. Pleurodesis with the administration of talc in hospitalized patients is the most ...

Antibiotic-Impregnated Central Venous Catheters Do Not Change Antibiotic Resistance Patterns.

Antibiotic-impregnated central venous catheters (CVCs) decrease the incidence of infection in high-risk patients. However, use of these catheters carries the hypothetical risk of inducing antibiotic r...

Medical and Biotech [MESH] Definitions

Catheters designed to be left within an organ or passage for an extended period of time.

Catheters inserted into various locations within the heart for diagnostic or therapeutic purposes.

Catheters inserted into the URINARY BLADDER or kidney for therapeutic or diagnostic purposes.

Catheters that are inserted into a large central vein such as a SUBCLAVIAN VEIN or FEMORAL VEIN.

A flexible, tubular device that is used to carry fluids into or from a blood vessel, hollow organ, or body cavity.

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