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The development of depression after a stroke is a serious condition that can have negative effects on thought, emotions, and overall daily functioning, particularly in the first year following the stroke. Evidence suggests that antidepressants may be used to prevent post-stroke depression. This study will treat nondepressed stroke patients with antidepressants or problem solving therapy (PST) to determine the most effective treatments for preventing depression.
Participants in this study will be randomly assigned to receive PST, escitalopram, or placebo (an inactive pill) for 12 months. Participants who display depressive symptoms for 2 weeks or more will be removed from the study. After 12 months, treatment will be discontinued and participants will be monitored for an additional 6 months.
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Prevention
Problem Solving Therapy, Escitalopram, Placebo
University of Chicago
Active, not recruiting
National Institute of Mental Health (NIMH)
Published on BioPortfolio: 2014-08-27T03:54:51-0400
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Instructional use of examples or cases to teach using problem-solving skills and critical thinking.
Trial-and-error methods of problem-solving used when an algorithmic approach is impractical
Application of computer programs designed to assist the physician in solving a diagnostic problem.
A learning situation involving more than one alternative from which a selection is made in order to attain a specific goal.
Experience-based techniques for problem-solving, learning, and discovery that find a solution which is not guaranteed to be optimal, but sufficient for a given set of goals.
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