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Biliary Atresia Research Consortium

2014-08-27 03:55:12 | BioPortfolio

Summary

Biliary atresia and idiopathic neonatal hepatitis are the most common causes of jaundice and hyperbilirubinemia that continue beyond the newborn period. The long term goal of the Biliary Atresia Research Consortium (BARC) is to establish a database of clinical information and serum and tissue samples from children with biliary atresia (BA) and idiopathic neonatal hepatitis (INH) to facilitate research and to perform clinical, epidemiological and therapeutic trials in these two important pediatric liver diseases.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Biliary Atresia

Location

University of California
San Francisco
California
United States
94143

Status

Recruiting

Source

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:55:12-0400

Clinical Trials [382 Associated Clinical Trials listed on BioPortfolio]

Intestinal Microbiome Composition in Infants With Biliary Atresia (BA)

A prospective observational study in infants with biliary atresia and controls to determine whether the composition of the intestinal microbiome is specific for biliary atresia will be con...

Development and Validation of a Screening Score for the Biliary Atresia in Infantile Cholestasis: A Prospective Study

Better survival and prognosis of biliary atresia (BA) depend on early diagnosis and timely Kasai portoenterostomy. Identifying BA from other causes of infantile cholestasis at early stage ...

RCT of Steroids Following Kasai Portoenterostomy for Biliary Atresia.

Biliary atresia is a congenital disorder of bile duct development or destruction of established but immature bile ducts. The study tests the hypothesis that post-operative steroids improv...

Biliary Atresia Study in Infants and Children

Little is known about the factors that cause biliary atresia nor the factors that influence disease progression. The purpose of this study is to collect the pertinent clinical information,...

GCSF Adjunct Therapy for Biliary Atresia

The Investigators propose to test the hypothesis that GCSF therapy enhances the clinical outcome of Kasai operated Biliary Atresia (BA) patients. In this study, Investigators will conduct ...

PubMed Articles [451 Associated PubMed Articles listed on BioPortfolio]

MULTIVARIATE ANALYSIS OF BILIARY FLOW-RELATED FACTORS AND POST-KASAI SURVIVAL IN BILIARY ATRESIA PATIENTS.

Biliary atresia represents the most common surgically treatable cause of cholestasis in newborns. If not corrected, secondary biliary cirrhosis invariably results.

Correctable biliary atresia and cholangiocarcinoma: a case report of a 63-year-old patient.

Although cancer occurrence following surgery for biliary atresia has gradually increased, the development of cholangiocarcinoma in a native liver survivor of biliary atresia is extremely rare.

Gene Expression Signatures Associated With Survival Times of Pediatric Patients With Biliary Atresia Identify Potential Therapeutic Agents.

Little is known about the factors that affect outcomes of patients with biliary atresia and there are no medical therapies that increase biliary drainage.

Management of Biliary Atresia in France 1986-2015: Long Term Results.

This study analyses the prognosis of Biliary Atresia (BA) in France since 1986, when both Kasai operation (KOp) and Liver Transplantation (LT) became widely available.

Gut microbial profile is altered in biliary atresia.

Biliary atresia (BA) is a progressive fibro-inflammatory cholangiopathy with an unclear etiology. Various liver disorders are associated with an altered microbiome. However, gut microbiome in BA remai...

Medical and Biotech [MESH] Definitions

Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.

Operation for biliary atresia by anastomosis of the bile ducts into the jejunum or duodenum.

Abnormal passage in any organ of the biliary tract or between biliary organs and other organs.

Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.

Infection of the biliary passages with CLONORCHIS SINENSIS, also called Opisthorchis sinensis. It may lead to inflammation of the biliary tract, proliferation of biliary epithelium, progressive portal fibrosis, and sometimes bile duct carcinoma. Extension to the liver may lead to fatty changes and cirrhosis. (From Dorland, 27th ed)

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