Advertisement

Topics

Magnetic Resonance Imaging of the Brain in Emotional Processing

2014-08-27 03:55:13 | BioPortfolio

Summary

This study will use magnetic resonance imaging (MRI) to identify brain regions involved in performing certain tasks, especially those involving emotions. MRI is a diagnostic tool that uses a strong magnetic field and radio waves to produce images of structural and chemical changes in the brain. The study will also examine which MRI techniques are best to use when scanning brain areas involved in different emotions.

Healthy normal volunteers between 18 and 40 years of age who are right-handed and are native English speakers may be eligible for this study. Individuals with a history of neurological disease, post-traumatic stress disorder or other psychiatric disorder, or who have a history of physical or sexual abuse may not participate. Candidates will be screened with a written questionnaire and a medical history, including psychiatric and neurological information.

Participants will perform tasks involving emotions while undergoing MRI scanning. For this procedure, the subject lies on a table in a narrow metal cylinder (the scanner) containing a magnetic field. Scanning time varies from 20 minutes to 3 hours, with most scans lasting between 45 and 90 minutes. The subject is asked to lie still for up to 10 minutes at a time. During the scan, the subject performs simple tasks involving the viewing of pictures on a screen. Other tasks involve viewing pictures and responding to them by pressing buttons. Some pictures are violent or pornographic, while others are pleasant to view. Of a total of 162 pictures, 30 percent are categorized as graphic and possibly disturbing.

Description

The purpose of the protocol is to localize the neural regions and systems mediating the forms of knowledge representations hypothesized by the principal investigator to be stored in the human prefrontal cortex. Utilizing experimental neuropsychological tasks during functional MRI on healthy adult volunteers, we will investigate hypotheses regarding the role of the ventromedial prefrontal cortex in social cognition and emotional processing as opposed to the dorsolateral prefrontal cortex, involved in nonsocial-events (planning, problem solving, economic exchange and reasoning). We will also attempt to determine the relationship between non-frontal neural structures involved in emotional expression, such as the amygdala, and those frontal neural structures involved in executive functions that may modulate emotion. Another goal of our study is to test different fMRI sequences to determine which one gives us the best quality of signal in the amygdala and orbitofrontal cortex (affected by signal drop-out due to magnetic susceptibility artifacts). The data that we collect in this protocol will be of value in (1) identifying a set of neural regions and distributed networks mediating the forms of knowledge representation stored in the prefrontal cortex, and (2) contributing to optimization of functional imaging of the amygdala and orbitofrontal cortex at high field strength (3 Tesla). We will also use the data obtained in these studies to constrain theories of frontal lobe function and to provide evidence for the role of specific frontal cortex sectors in specific cognitive functions.

Study Design

N/A

Conditions

Healthy

Location

National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda
Maryland
United States
20892

Status

Completed

Source

National Institutes of Health Clinical Center (CC)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:55:13-0400

Clinical Trials [3 Associated Clinical Trials listed on BioPortfolio]

Study Evaluating MOA-728 Administered in Healthy Men

Absorption, distribution, metabolism, and excretion (ADME) study with 14C in healthy young men.

The Healthy Cookie Study: Understanding How Healthy Cookies Affect Fat in the Blood,

The purpose of this study is to understand how consuming healthy cookies every day for two weeks will affect different types of fat in the blood. Specifically, the overall goal of this stu...

Study Evaluating IMA-026 in Healthy Subjects

To assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of IMA-026 administered subcutaneously (SC) or intravenously (IV) in healthy adults.

PubMed Articles [4379 Associated PubMed Articles listed on BioPortfolio]

Defining and Estimating Healthy Aging in Spain: A Cross-sectional Study.

Using an operational continuum of healthy aging developed by U.S. researchers, we sought to estimate the prevalence of healthy aging among older Spaniards, inform the development of a definition of he...

Effects of a healthy-eater self-schema and nutrition literacy on healthy-eating behaviors among Taiwanese college students.

Unhealthy eating behaviors contribute to obesity and chronic illness. This study examined the relative contributions of a healthy-eater self-schema (a self-conception as a healthy eater) and nutrition...

Healthy China 2030, a breakthrough for improving health.

China has the largest population in the world, and its health levels have greatly affected the healthy development of the population of the world. Healthy China 2030 is a breakthrough for ensuring tha...

Healthy People for the 21st Century: Understanding Use of Healthy People 2020 as a Web-Based Initiative.

This study assesses how the nation's preeminent health promotion and disease prevention initiative, Healthy People, is utilized by key stakeholders.

Healthy diets and a healthy planet.

Medical and Biotech [MESH] Definitions

Healthy People Programs are a set of health objectives to be used by governments, communities, professional organizations, and others to help develop programs to improve health. It builds on initiatives pursued over the past two decades beginning with the 1979 Surgeon General's Report, Healthy People, Healthy People 2000: National Health Promotion and Disease Prevention Objectives, and Healthy People 2010. These established national health objectives and served as the basis for the development of state and community plans. These are administered by the Office of Disease Prevention and Health Promotion (ODPHP). Similar programs are conducted by other national governments.

Governmental guidelines and objectives pertaining to public food supply and nutrition including recommendations for healthy diet and changes in food habits to ensure healthy diet.

Surgical reinnervation of a denervated peripheral target using a healthy donor nerve and/or its proximal stump. The direct connection is usually made to a healthy postlesional distal portion of a non-functioning nerve or implanted directly into denervated muscle or insensitive skin. Nerve sprouts will grow from the transferred nerve into the denervated elements and establish contact between them and the neurons that formerly controlled another area.

Process of evaluating the health of a patient and determining if they are healthy enough for surgery.

Dietary patterns which have been found to be important in reducing disease risk.

More From BioPortfolio on "Magnetic Resonance Imaging of the Brain in Emotional Processing"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Radiology
Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...

Alzheimer's Disease
Of all the types of Dementia, Alzheimer's disease is the most common, affecting around 465,000 people in the UK. Neurons in the brain die, becuase  'plaques' and 'tangles' (mis-folded proteins) form in the brain. People with Al...


Searches Linking to this Trial