Advertisement

Topics

Comparing Effects of 3 Sources of Garlic on Cholesterol Levels

2014-08-27 03:55:26 | BioPortfolio

Summary

The purpose of this study is to determine whether fresh garlic can positively affect cholesterol in adults with moderately high cholesterol levels. This study will also determine whether the same effects can be found for two main types of garlic supplements: a dried powdered garlic (designed to yield the same effect as fresh garlic) and an aged garlic extract preparation.

Description

Garlic supplements are the most consumed herbal products in the United States. The most common health claim made for garlic supplements is cholesterol lowering activity. This claim has not been supported by recent clinical trials and meta-analyses. However, data suggest that it is not necessarily the garlic that has been ineffective, but rather the particular garlic preparations being used. To date, the predominant type of garlic preparation used in these clinical trials has been dried garlic powders. A few clinical trials have reported beneficial lipid effects using an aged garlic extract, and only a small number of inconclusive uncontrolled trials have used fresh garlic. A rigorous trial directly comparing different types of garlic preparations for their effects on serum lipids is needed.

Adults with moderately elevated low density lipoprotein cholesterol (LDL-C) will be randomized to one of four groups for 6 months: fresh garlic, dried powdered garlic tablets, aged garlic extract tablets, or placebo control. The fresh garlic will be provided to patients with "study sandwiches"; all other groups will receive the same study sandwiches without the garlic. All patients will take daily study tablets, but the tablet assignment will be double-blind. Patients will pick up study sandwiches twice a week and study tablets once every 2 weeks for 28 weeks. Blood samples will be taken once a month, with additional blood draws at the start and end of the study.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Conditions

Hypercholesterolemia

Intervention

Fresh garlic or garlic supplements

Location

Stanford Center for Research in Disease Prevention
Palo Alto
California
United States
94304-1583

Status

Completed

Source

National Center for Complementary and Alternative Medicine (NCCAM)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:55:26-0400

Clinical Trials [510 Associated Clinical Trials listed on BioPortfolio]

Allicin Bioavailability From Garlic Supplements and Garlic Foods

This study will measure the bioavailability of allicin, the main active compound of garlic, from garlic supplements and garlic foods (raw, cooked, processed) so that - supplement manuf...

Effect of Garlic Supplements on Opioids in Healthy Volunteers

RATIONALE: Garlic supplements may change the effectiveness of oxycodone used to relieve moderate or severe pain. PURPOSE: This randomized phase I trial is studying how garlic supplements ...

Omeprazole and Amoxicillin and/or Vitamin and Mineral Supplements and/or Garlic Supplements in Preventing Stomach Cancer in Patients With Precancerous Stomach Lesions

RATIONALE: Chemoprevention is the use of certain drugs or supplements to keep cancer from forming, growing, or coming back. The use of omeprazole and amoxicillin and/or vitamin and mineral...

Garlic in Hyperlipidemia Caused by HAART

The purpose of this study is to test the effectiveness and tolerability of garlic pills in lowering cholesterol and triglycerides in hyperlipidemic HIV-infected individuals who are being t...

Docetaxel Plus Garlic in Treating Patients With Locally Advanced or Metastatic Breast Cancer

RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether garlic supplemen...

PubMed Articles [1163 Associated PubMed Articles listed on BioPortfolio]

The inhibition effect of garlic-derived compounds on human immunodeficiency virus type 1 and saquinavir.

Garlic has been used as a traditional medicine to treat various diseases. Garlic reduces the risk of some diseases. This protective effect is due to the organosulfur compounds of garlic. The aim of th...

Antioxidant activities of garlic polysaccharide and its phosphorylated derivative.

Garlic polysaccharide was extracted by hot water method and phosphorylated. The phosphorylated garlic polysaccharide was confirmed by IR, C NMR and P NMR spectra. The scavenging effects of garlic poly...

Preparation and antioxidant activity of carboxymethylated garlic polysaccharide.

Extraction and antioxidant activity of carboxymethylated garlic polysaccharide were investigated. The crude polysaccharide was extracted by the hot-water method. The peak appearing around 177 in C NMR...

Garlic (Allium sativum) improves anxiety- and depressive-related behaviors and brain oxidative stress in diabetic rats.

This study investigated the effects of garlic on anxiety- and depression-related behaviors and brain oxidative markers in streptozotocin (STZ)-induced diabetes in rats. Fifty-six male Wistar rats were...

Natural products show diverse mechanisms of action against C. difficile.

To investigate the mechanisms of action of natural products with bactericidal (cinnamon root powder, peppermint oil, trans-cinnamaldehyde, menthol and zingerone) or bacteriostatic (fresh garlic bulb e...

Medical and Biotech [MESH] Definitions

Mildly aromatic herb in the Allium genus related to ONIONS and garlic used in SPICES.

A genus of ALGAE in the family CHARACEAE. They have a strong garlic-like odor and are an important food source for waterfowl.

Allium sativum. One of the Liliaceae used as a spice and traditional remedy. It contains allicin, the pungent active ingredient, which may reduce blood cholesterol and inhibit platelet aggregation.

A partially enclosed body of water, and its surrounding coastal habitats, where saltwater from the ocean mixes with fresh water from rivers or streams. The resulting mixture of seawater and fresh water is called brackish water and its salinity can range from 0.5 to 35 ppt. (accessed http://oceanservice.noaa.gov/education/kits/estuaries/estuaries01_whatis.html)

An allylamine derivative that binds BILE ACIDS in the intestine and is used as an ANTICHOLESTEREMIC AGENT in the treatment of HYPERCHOLESTEROLEMIA and HYPERLIPIDEMIAS.

More From BioPortfolio on "Comparing Effects of 3 Sources of Garlic on Cholesterol Levels"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topic

Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...


Searches Linking to this Trial